dc.contributor.author
Long, Yanping
dc.contributor.author
Dimde, Mathias
dc.contributor.author
Adler, Julia M.
dc.contributor.author
Vidal, Ricardo Martin
dc.contributor.author
Povolotsky, Tatyana L.
dc.contributor.author
Nickl, Philip
dc.contributor.author
Achazi, Katharina
dc.contributor.author
Trimpert, Jakob
dc.contributor.author
Kaufer, Benedikt B.
dc.contributor.author
Haag, Rainer
dc.contributor.author
Nie, Chuanxiong
dc.date.accessioned
2024-12-13T07:52:12Z
dc.date.available
2024-12-13T07:52:12Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/45736
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-45449
dc.description.abstract
Mucus is the first defense barrier against viruses in the human immune system. Inspired by the mucus structure, we designed a highly sulfated hydrogel to bind viruses and prevent infection of the underlying cells. The hydrogel was formed by gelation of sulfated cellulose nanofiber (SCNF) with Ca2+. SCNF exhibited a mucin-like nanofiber structure with high numbers of sulfated groups. Based on the electrostatic interactions with a virus, SCNF could efficiently inhibit herpes simplex virus-1 (HSV-1) infection with a half-maximal inhibitory concentration (IC50) of 0.43 μg/mL, which is comparable to that of heparin (IC50 = 0.30 μg/mL). Benefiting from the multiporous structure and sulfate groups, the Ca2+-SCNF hydrogel could efficiently trap HSV-1 and inhibit the virus from attacking the underlying cells in a transwell model. Furthermore, SCNF also inhibited SARS-CoV-2 infection in a similar experimental setting. By integrating the advantages of high and broad-spectrum virus inhibitory activity as well as low toxicity, it is believed that the Ca2+-SCNF hydrogel can promote the development of highly biocompatible and efficient antiviral material with “binding and inhibition” capability and other diverse strategies.
en
dc.format.extent
10 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
mucin-mimetic biopolymeric nanofibers
en
dc.subject
mucus-like hydrogels
en
dc.subject
virus binding and inhibition
en
dc.subject
live-cell imaging
en
dc.subject
transwell assay
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
dc.title
Sulfated Cellulose Nanofiber Hydrogel with Mucus-Like Activities for Virus Inhibition
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1021/acsami.4c17998
dcterms.bibliographicCitation.journaltitle
ACS Applied Materials & Interfaces
dcterms.bibliographicCitation.number
49
dcterms.bibliographicCitation.pagestart
67504
dcterms.bibliographicCitation.pageend
67513
dcterms.bibliographicCitation.volume
16
dcterms.bibliographicCitation.url
https://doi.org/10.1021/acsami.4c17998
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation
Veterinärmedizin
refubium.affiliation.other
Institut für Chemie und Biochemie

refubium.affiliation.other
Institut für Virologie

refubium.funding
ACS Publications
refubium.note.author
Die Publikation wurde aus Open Access Publikationsgeldern der Freien Universität Berlin gefördert.
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1944-8252