dc.contributor.author
Arias-Rojas, Aranzazu
dc.contributor.author
Arifah, Adini Q.
dc.contributor.author
Angelidou, Georgia
dc.contributor.author
Alshaar, Belal
dc.contributor.author
Schombel, Ursula
dc.contributor.author
Forest, Emma
dc.contributor.author
Frahm, Dagmar
dc.contributor.author
Brinkmann, Volker
dc.contributor.author
Paczia, Nicole
dc.contributor.author
Beisel, Chase L.
dc.date.accessioned
2024-09-11T08:52:48Z
dc.date.available
2024-09-11T08:52:48Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/44901
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-44611
dc.description.abstract
Multiple peptide resistance factor (MprF) confers resistance to cationic antimicrobial peptides (AMPs) in several pathogens, thereby enabling evasion of the host immune response. The role of MprF in commensals remains, however, uncharacterized. To close this knowledge gap, we used a common gut commensal of animals, Lactiplantibacillus plantarum, and its natural host, the fruit fly Drosophila melanogaster, as an experimental model to investigate the role of MprF in commensal-host interactions. The L. plantarum ΔmprF mutant that we generated exhibited deficiency in the synthesis of lysyl-phosphatidylglycerol (Lys-PG), resulting in increased negative cell surface charge and increased susceptibility to AMPs. Susceptibility to AMPs had no effect on ΔmprF mutant’s ability to colonize guts of uninfected flies. However, we observed significantly reduced abundance of the ΔmprF mutant after infection-induced inflammation in the guts of wild-type flies but not of flies lacking AMPs. Additionally, we found that the ΔmprF mutant compared to wild-type L. plantarum induces a stronger intestinal immune response in flies due to the increased release of immunostimulatory peptidoglycan fragments, indicating an important role of MprF in promoting host tolerance to commensals. Our further analysis suggests that MprF-mediated lipoteichoic acid modifications are involved in host immunomodulation. Overall, our results demonstrate that MprF, besides its well-characterized role in pathogen immune evasion and virulence, is also an important commensal resilience factor.
en
dc.format.extent
29 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Escherichia coli
en
dc.subject
Staphylococcus aureus
en
dc.subject
Drosophila melanogaster
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.title
MprF-mediated immune evasion is necessary for Lactiplantibacillus plantarum resilience in the Drosophila gut during inflammation
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e1012462
dcterms.bibliographicCitation.doi
10.1371/journal.ppat.1012462
dcterms.bibliographicCitation.journaltitle
PLOS Pathogens
dcterms.bibliographicCitation.number
8
dcterms.bibliographicCitation.volume
20
dcterms.bibliographicCitation.url
https://doi.org/10.1371/journal.ppat.1012462
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1553-7374
refubium.resourceType.provider
WoS-Alert