dc.contributor.author
Haltenhof, Tom
dc.contributor.author
Preußner, Marco
dc.contributor.author
Heyd, Florian
dc.date.accessioned
2024-09-05T08:58:23Z
dc.date.available
2024-09-05T08:58:23Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/44804
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-44514
dc.description.abstract
Temperature-dependent alternative splicing (AS) is a crucial mechanism for organisms to adapt to varying environmental temperatures. In mammals, even slight fluctuations in body temperature are sufficient to drive significant AS changes in a concerted manner. This dynamic regulation allows organisms to finely tune gene expression and protein isoform diversity in response to temperature cues, ensuring proper cellular function and physiological adaptation. Understanding the molecular mechanisms underlying temperature-dependent AS thus provides valuable insights into the intricate interplay between environmental stimuli and gene expression regulation. In this review, we provide an overview of recent advances in understanding temperature-regulated AS across various biological processes and systems. We will discuss the machinery sensing and translating temperature cues into changed AS patterns, the adaptation of the splicing regulatory machinery to extreme temperatures, the role of temperature-dependent AS in shaping the transcriptome, functional implications and the development of potential therapeutics targeting temperature-sensitive AS pathways.
en
dc.format.extent
15 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
alternative splicing
en
dc.subject
body temperature
en
dc.subject
nonsense-mediated decay
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.title
Thermoregulated transcriptomics: the molecular basis and biological significance of temperature-dependent alternative splicing
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1042/BCJ20230410
dcterms.bibliographicCitation.journaltitle
Biochemical Journal
dcterms.bibliographicCitation.number
15
dcterms.bibliographicCitation.pagestart
999
dcterms.bibliographicCitation.pageend
1013
dcterms.bibliographicCitation.volume
481
dcterms.bibliographicCitation.url
https://doi.org/10.1042/BCJ20230410
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie

refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1470-8728
refubium.resourceType.provider
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