dc.contributor.author
Jhelum, Hina
dc.contributor.author
Kaufer, Benedikt
dc.contributor.author
Denner, Joachim
dc.date.accessioned
2024-08-29T08:16:55Z
dc.date.available
2024-08-29T08:16:55Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/44721
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-44432
dc.description.abstract
Detection methods have been developed to prevent transmission of zoonotic or xenozoonotic porcine viruses after transplantation of pig organs or cells to the recipient (xenotransplantation). Eleven xenotransplantation-relevant viruses, including porcine cytomegalovirus, porcine roseolovirus (PCMV/PRV), porcine lymphotropic herpesviruses -1, -2, -3 (PLHV-1, 2, 3), porcine parvovirus (PPV), porcine circovirus 2, 3, 4 (PCV2, 3, 4), hepatitis E virus genotype 3 (HEV3), porcine endogenous retrovirus-C (PERV-C), and recombinant PERV-A/C have been selected. In the past, several pig breeds, minipigs, and genetically modified pigs generated for xenotransplantation had been analyzed using these methods. Here, spleen, liver, and blood samples from 10 German slaughterhouse pigs were screened using both PCR-based and immunological assays. Five viruses: PCMV/PRV, PLHV-1, PLHV-3, and PERV-C, were found in all animals, and PCV3 in one animal. Some animals were latently infected with PCMV/PRV, as only virus-specific antibodies were detected. Others were also PCR positive in the spleen and/or liver, indicative of an ongoing infection. These results provide important information on the viruses that infect German slaughterhouse pigs, and together with the results of previous studies, they reveal that the methods and test strategies efficiently work under field conditions.
en
dc.format.extent
15 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
porcine viruses
en
dc.subject
xenotransplantation
en
dc.subject
virus safety
en
dc.subject
herpes viruses
en
dc.subject
porcine endogenous retroviruses
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::636 Viehwirtschaft
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
dc.title
Application of Methods Detecting Xenotransplantation-Relevant Viruses for Screening German Slaughterhouse Pigs
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1119
dcterms.bibliographicCitation.doi
10.3390/v16071119
dcterms.bibliographicCitation.journaltitle
Viruses
dcterms.bibliographicCitation.number
7
dcterms.bibliographicCitation.originalpublishername
MDPI
dcterms.bibliographicCitation.volume
16
dcterms.bibliographicCitation.url
https://doi.org/10.3390/v16071119
refubium.affiliation
Veterinärmedizin
refubium.affiliation.other
Institut für Virologie
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refubium.note.author
Die Publikation wurde aus Open Access Publikationsgeldern der Freien Universität Berlin gefördert.
de
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1999-4915