dc.contributor.author
Talenti, Andrea
dc.contributor.author
Wilkinson, Toby
dc.contributor.author
Cook, Elizabeth A.
dc.contributor.author
Hemmink, Johanneke D.
dc.contributor.author
Paxton, Edith
dc.contributor.author
Mutinda, Matthew
dc.contributor.author
Ngulu, Stephen D.
dc.contributor.author
Jayaraman, Siddharth
dc.contributor.author
Bishop, Richard P.
dc.contributor.author
Obara, Isaiah
dc.date.accessioned
2024-08-14T13:54:46Z
dc.date.available
2024-08-14T13:54:46Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/44574
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-44286
dc.description.abstract
The African buffalo (Syncerus caffer) is a wild bovid with a historical distribution across much of sub-Saharan Africa. Genomic analysis can provide insights into the evolutionary history of the species, and the key selective pressures shaping populations, including assessment of population level differentiation, population fragmentation, and population genetic structure. In this study we generated the highest quality de novo genome assembly (2.65 Gb, scaffold N50 69.17 Mb) of African buffalo to date, and sequenced a further 195 genomes from across the species distribution. Principal component and admixture analyses provided little support for the currently described four subspecies. Estimating Effective Migration Surfaces analysis suggested that geographical barriers have played a significant role in shaping gene flow and the population structure. Estimated effective population sizes indicated a substantial drop occurring in all populations 5-10,000 years ago, coinciding with the increase in human populations. Finally, signatures of selection were enriched for key genes associated with the immune response, suggesting infectious disease exert a substantial selective pressure upon the African buffalo. These findings have important implications for understanding bovid evolution, buffalo conservation and population management.
en
dc.format.extent
14 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Population genetics
en
dc.subject
African buffalo
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
dc.title
Continent-wide genomic analysis of the African buffalo (Syncerus caffer)
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
792
dcterms.bibliographicCitation.doi
10.1038/s42003-024-06481-2
dcterms.bibliographicCitation.journaltitle
Communications Biology
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.volume
7
dcterms.bibliographicCitation.url
https://doi.org/10.1038/s42003-024-06481-2
refubium.affiliation
Veterinärmedizin
refubium.affiliation.other
Institut für Parasitologie und Tropenveterinärmedizin
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refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2399-3642
refubium.resourceType.provider
WoS-Alert