dc.contributor.author
Ghazawi, Akela
dc.contributor.author
Anes, Febin
dc.contributor.author
Mouftah, Shaimaa
dc.contributor.author
Elbediwi, Mohammed
dc.contributor.author
Baig, Awase
dc.contributor.author
Alketbi, Muna
dc.contributor.author
Almazrouei, Fatema
dc.contributor.author
Alhashmi, Mariam
dc.contributor.author
Alzarooni, Norah
dc.contributor.author
Manzoor, Ashrat
dc.contributor.author
Habib, Ihab
dc.contributor.author
Strepis, Nikolaos
dc.contributor.author
Nabi, Anju
dc.contributor.author
Khan, Mushtaq
dc.date.accessioned
2024-08-08T14:57:38Z
dc.date.available
2024-08-08T14:57:38Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/44466
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-44178
dc.description.abstract
Enterobacter hormaechei has emerged as a significant pathogen within healthcare settings due to its ability to develop multidrug resistance (MDR) and survive in hospital environments. This study presents a genome-based analysis of carbapenem-resistant Enterobacter hormaechei isolates from two major hospitals in the United Arab Emirates. Eight isolates were subjected to whole-genome sequencing (WGS), revealing extensive resistance profiles including the blaNDM-1, blaOXA-48, and blaVIM-4 genes. Notably, one isolate belonging to ST171 harbored dual carbapenemase genes, while five isolates exhibited colistin resistance without mcr genes. The presence of the type VI secretion system (T6SS), various adhesins, and virulence genes contributes to the virulence and competitive advantage of the pathogen. Additionally, our isolates (87.5%) possessed ampC β-lactamase genes, predominantly blaACT genes. The genomic context of blaNDM-1, surrounded by other resistance genes and mobile genetic elements, highlights the role of horizontal gene transfer (HGT) in the spread of resistance. Our findings highlight the need for rigorous surveillance, strategic antibiotic stewardship, and hospital-based WGS to manage and mitigate the spread of these highly resistant and virulent pathogens. Accurate identification and monitoring of Enterobacter cloacae complex (ECC) species and their resistance mechanisms are crucial for effective infection control and treatment strategies.
en
dc.format.extent
16 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Enterobacter hormachei
en
dc.subject
whole-genome sequencing
en
dc.subject
incompatibility types
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
dc.title
Genomic Study of High-Risk Clones of Enterobacter hormaechei Collected from Tertiary Hospitals in the United Arab Emirates
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
592
dcterms.bibliographicCitation.doi
10.3390/antibiotics13070592
dcterms.bibliographicCitation.journaltitle
Antibiotics
dcterms.bibliographicCitation.number
7
dcterms.bibliographicCitation.originalpublishername
MDPI
dcterms.bibliographicCitation.volume
13
dcterms.bibliographicCitation.url
https://doi.org/10.3390/antibiotics13070592
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Biologie
![Dieser Normdateneintrag wurde von einer Benutzerin oder einem Benutzer als gültig bestätigt.](/cache_202e45ad85b55efaeb29160f63cd3f3b/themes/FuCD/images/authority_control/invisible.gif)
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2079-6382