dc.contributor.author
Dahlmann, Sebastian
dc.contributor.author
Bressem, Keno
dc.contributor.author
Bashian, Behschad
dc.contributor.author
Ulas, Sevtap Tugce
dc.contributor.author
Rattunde, Maximilian
dc.contributor.author
Busch, Felix
dc.contributor.author
Makowski, Marcus R.
dc.contributor.author
Ziegeler, Katharina
dc.contributor.author
Adams, Lisa
dc.date.accessioned
2024-08-02T09:14:24Z
dc.date.available
2024-08-02T09:14:24Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/44382
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-44094
dc.description.abstract
Purpose To examine sex-specific differences in renal cell carcinoma (RCC) in relation to abdominal fat accumulation, psoas muscle density, tumor size, pathology, and survival, and to evaluate possible associations with RCC characteristics and outcome. Methods A total of 470 patients with RCC who underwent nephrectomy between 2006 and 2019 were included in this retrospective study. Specific characteristics of RCC patients were collected, including sex, height, tumor size, grade, and data on patient survival, if available. Abdominal fat measurements and psoas muscle area were determined at the level of L3 (cm(2)). Results Women had a higher subcutaneous (p < 0.001) and men had a higher visceral fat area, relative proportion of visceral fat area (p < 0.001), and psoas muscle index (p < 0.001). Logistic regression analysis showed an association between higher psoas muscle index and lower grade tumors [women: odds ratio (OR) 0.94, 95% confidence interval (CI) 0.89-0.99, p = 0.011; men: OR 0.97 (95% CI, 0.95-0.99, p = 0.012]. Univariate regression analysis demonstrated an association between psoas muscle index and overall survival (women: OR 1.41, 95% CI 1.03-1.93, p = 0.033; men: OR 1.62 (95% CI, 1.33-1.97, p < 0.001). In contrast, there were no associations between abdominal fat measurements and tumor size, grade, or survival. Also, there were no sex-specific differences in tumor size or tumor grades. Conclusions A higher preoperative psoas muscle index was independently associated with overall survival in RCC patients, with a stronger association in men compared with women. In addition, the psoas muscle index showed an inverse association with tumor grade, whereby this association was slightly more pronounced in women than in men.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Body Composition
en
dc.subject
Carcinoma, Renal Cell
en
dc.subject
Kidney Neoplasms
en
dc.subject
Sex Characteristics
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Sex Differences in Renal Cell Carcinoma: The Importance of Body Composition
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1245/s10434-022-12738-z
dcterms.bibliographicCitation.journaltitle
Annals of Surgical Oncology
dcterms.bibliographicCitation.number
2
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.pagestart
1269
dcterms.bibliographicCitation.pageend
1276
dcterms.bibliographicCitation.volume
30
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
36352298
dcterms.isPartOf.issn
1068-9265
dcterms.isPartOf.eissn
1534-4681