dc.contributor.author
Wiese, Lorenz
dc.contributor.author
Kolbe, Sophie M.
dc.contributor.author
Weber, Manuela
dc.contributor.author
Ludlow, Martin
dc.contributor.author
Christmann, Mathias
dc.date.accessioned
2024-07-03T12:57:40Z
dc.date.available
2024-07-03T12:57:40Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/44096
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-43806
dc.description.abstract
The first chemical synthesis of the phloroglucinol meroterpenoid cleistocaltone A (1) is presented. This compound, previously isolated from Cleistocalyx operculatus was reported to show promising antiviral properties. Based on a modified biosynthesis proposal, a synthetic strategy was devised featuring an intramolecular Diels–Alder reaction and an epoxidation/elimination sequence to generate the allyl alcohol handle in the side chain. The strategy was successfully executed and synthetic cleistcaltone A was evaluated against a contemporary RSV-A strain.
en
dc.format.extent
5 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
cleistocaltone A
en
dc.subject
biological evaluation
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
dc.title
Synthesis and biological evaluation of cleistocaltone A, an inhibitor of respiratory syncytial virus (RSV)
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1039/D4SC01897D
dcterms.bibliographicCitation.journaltitle
Chemical Science
dcterms.bibliographicCitation.number
26
dcterms.bibliographicCitation.pagestart
10121
dcterms.bibliographicCitation.pageend
10125
dcterms.bibliographicCitation.volume
15
dcterms.bibliographicCitation.url
https://doi.org/10.1039/D4SC01897D
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie
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refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2041-6539
refubium.resourceType.provider
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