dc.contributor.author
Ma, Guoxin
dc.contributor.author
Braatz, Daniel
dc.contributor.author
Tang, Peng
dc.contributor.author
Yang, Yian
dc.contributor.author
Quaas, Elisa
dc.contributor.author
Ludwig, Kai
dc.contributor.author
Ma, Nan
dc.contributor.author
Sun, Huanli
dc.contributor.author
Zhong, Zhiyuan
dc.contributor.author
Haag, Rainer
dc.date.accessioned
2024-07-16T10:21:07Z
dc.date.available
2024-07-16T10:21:07Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/43981
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-43690
dc.description.abstract
Supramolecular delivery systems with the prolonged circulation, the potential for diverse functionalization, and few toxin-related limitations have been extensively studied. For the present study, we constructed a linear polyglycerol-shelled polymersome attached with the anti-HER-2-antibody trastuzumab. We then covalently loaded the anticancer drug DM1 in the polymersome via dynamic disulfide bonding. The resulted trastuzumab-polymersome-DM1 (Tra-PS-DM1) exhibits a mean size of 95.3 nm and remarkable drug loading efficiency % of 99.3%. In addition to its superior stability, we observed the rapid release of DM1 in a controlled manner under reductive conditions. Compared to the native polymersomes, Tra-PS-DM1 has shown greatly improved cellular uptake and significantly reduced IC50 up to 17-fold among HER-2-positive cancer cells. Moreover, Tra-PS-DM1 demonstrated superb growth inhibition of HER-2-positive tumoroids; specifically, BT474 tumoroids shrunk up to 62% after 12 h treatment. With exceptional stability and targetability, the PG-shelled Tra-PS-DM1 appears as an attractive approach for HER-2-positive tumor treatment.
en
dc.format.extent
9 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Dynamic light scattering
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
dc.title
Polyglycerol-Shelled Reduction-Sensitive Polymersome for DM1 Delivery to HER-2-Positive Breast Cancer
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1021/acs.biomac.4c00512
dcterms.bibliographicCitation.journaltitle
Biomacromolecules
dcterms.bibliographicCitation.number
7
dcterms.bibliographicCitation.pagestart
4440
dcterms.bibliographicCitation.pageend
4448
dcterms.bibliographicCitation.volume
25
dcterms.bibliographicCitation.url
https://doi.org/10.1021/acs.biomac.4c00512
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie
refubium.funding
ACS Publications
refubium.note.author
Die Publikation wurde aus Open Access Publikationsgeldern der Freien Universität Berlin gefördert.
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1526-4602