dc.contributor.author
Thole, Linda Marie Laura
dc.contributor.author
Tóth, Laura
dc.contributor.author
Proß, Vanessa
dc.contributor.author
Siegle, Janine
dc.contributor.author
Stahl, Carolin
dc.contributor.author
Hermsdorf, Georg
dc.contributor.author
Knabe, Annette
dc.contributor.author
Winkler, Annika
dc.contributor.author
Schrezenmeier, Eva
dc.contributor.author
Ludwig, Carolin
dc.contributor.author
Eckert, Cornelia
dc.contributor.author
Eggert, Angelika
dc.contributor.author
Schrezenmeier, Hubert
dc.contributor.author
Sattler, Arne
dc.contributor.author
Schulte, Johannes H.
dc.contributor.author
Kotsch, Katja
dc.date.accessioned
2024-06-24T09:43:14Z
dc.date.available
2024-06-24T09:43:14Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/43933
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-43643
dc.description.abstract
Stem cell transplant recipients (SCTR) are imperiled to increased risks after SARS-CoV2 infection, supporting the need for effective vaccination strategies for this vulnerable group. With respect to pediatric patients, data on immunogenicity of SARS-CoV2 mRNA-based vaccination is limited. We therefore comprehensively examined specific humoral, B- and T cell responses in a cohort of 2-19 year old SCTR after the second and third vaccine dose. Only after booster vaccination, transplant recipients reached similar levels of vaccine-specific IgG, IgA and neutralizing antibodies against omicron variant as age-matched controls. Although frequencies of SARS-CoV2 specific B cells increased after the third dose, they were still fourfold reduced in patients compared to controls. Overall, the majority of individuals enrolled mounted SARS-CoV2 Spike protein-specific CD4+ T helper cell responses with patients showing significantly higher portions than controls after the third dose. With respect to functionality, however, SCTR were characterized by reduced frequencies of specific interferon gamma producing CD4+ T cells, along with an increase in IL-2 producers. In summary, our data identify distinct quantitative and qualitative impairments within the SARS-CoV2 vaccination specific B- and CD4+ T cell compartments. More importantly, humoral analyses highlight the need for a booster vaccination of SCTR particularly for development of neutralizing antibodies.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
mRNA vaccination
en
dc.subject
stem cell transplantation
en
dc.subject
cellular immunity
en
dc.subject
humoral immunity
en
dc.subject
antigen-specific immunity
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Impact of a booster dose on SARS-CoV2 mRNA vaccine-specific humoral-, B- and T cell immunity in pediatric stem cell transplant recipients
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1239519
dcterms.bibliographicCitation.doi
10.3389/fimmu.2023.1239519
dcterms.bibliographicCitation.journaltitle
Frontiers in Immunology
dcterms.bibliographicCitation.originalpublishername
Frontiers Media SA
dcterms.bibliographicCitation.volume
14
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
37942315
dcterms.isPartOf.eissn
1664-3224