dc.contributor.author
Doll, Christian
dc.contributor.author
Mrosk, Friedrich
dc.contributor.author
Freund, Lea
dc.contributor.author
Neumann, Felix
dc.contributor.author
Kreutzer, Kilian
dc.contributor.author
Voss, Jan
dc.contributor.author
Raguse, Jan-Dirk
dc.contributor.author
Beck, Marcus
dc.contributor.author
Böhmer, Dirk
dc.contributor.author
Rubarth, Kerstin
dc.contributor.author
Heiland, Max
dc.contributor.author
Koerdt, Steffen
dc.date.accessioned
2024-04-18T10:56:27Z
dc.date.available
2024-04-18T10:56:27Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/43114
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-42829
dc.description.abstract
In lateralized oral squamous cell carcinoma (OSCC) with ipsilateral cervical lymph node metastasis (CLNM), the surgical management of the unsuspicious contralateral neck remains a matter of debate. The aim of this study was to analyze this cohort and to compare the outcomes of patients with and without contralateral elective neck dissection (END). Material and Methods: A retrospective analysis of patients with lateralized OSCC, ipsilateral CLNM (pN+) and contralateral cN0-stage was performed. Patients were divided into two groups according to the surgical management of the contralateral neck: I: END; and II: no END performed. Adjuvant radiotherapy was applied bilaterally in both groups according to individual risk. Results: A total of 65 patients (group I: 16 (24.6%); group II: 49 (75.4%)) with a median follow-up of 28 months were included. Initially, there was no case of contralateral CLNM after surgery. During follow-up, 6 (9.2%) patients presented with recurrent CLNM. In 5 of these cases (7.7%), the contralateral neck (group I: 3/16 (18.8%); group II: 2/49 (4.1%)) was affected. Increased ipsilateral lymph node ratio was associated with contralateral CLNM (p = 0.07). END of the contralateral side showed no significant benefit regarding OS (p = 0.59) and RFS (p = 0.19). Conclusions: Overall, the risk for occult contralateral CLNM in patients with lateralized OSCC ipsilateral CLNM is low. Our data suggest that END should not be performed routinely in this cohort. Risk-adapted radiotherapy of the contralateral neck alone seems to be sufficient from the oncological point of view.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
oral squamous cell carcinoma
en
dc.subject
elective neck dissection
en
dc.subject
neck management
en
dc.subject
contralateral neck
en
dc.subject
contralateral metastasis
en
dc.subject
occult metastasis
en
dc.subject
de-escalation
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Management of the Contralateral Neck in Unilateral Node-Positive Oral Squamous Cell Carcinoma
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1088
dcterms.bibliographicCitation.doi
10.3390/cancers15041088
dcterms.bibliographicCitation.journaltitle
Cancers
dcterms.bibliographicCitation.number
4
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
15
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
36831429
dcterms.isPartOf.eissn
2072-6694