dc.contributor.author
Vetter, Valentin Max
dc.contributor.author
Drewelies, Johanna
dc.contributor.author
Sommerer, Yasmine
dc.contributor.author
Kalies, Christian Humberto
dc.contributor.author
Regitz-Zagrosek, Vera
dc.contributor.author
Bertram, Lars
dc.contributor.author
Gerstorf, Denis
dc.contributor.author
Demuth, Ilja
dc.date.accessioned
2024-03-18T14:22:46Z
dc.date.available
2024-03-18T14:22:46Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/42910
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-42626
dc.description.abstract
Adverse effects of psychological stress on physical and mental health, especially in older age, are well documented. How perceived stress relates to the epigenetic clock measure, DNA methylation age acceleration (DNAmAA), is less well understood and existing studies reported inconsistent results. DNAmAA was estimated from five epigenetic clocks (7-CpG, Horvath's, Hannum's, PhenoAge and GrimAge DNAmAA). Cohen's Perceived Stress Scale (PSS) was used as marker of psychological stress. We analyzed data from 1,100 Berlin Aging Study II (BASE-II) participants assessed as part of the GendAge study (mean age = 75.6 years, SD = 3.8 years, 52.1% women). In a first step, we replicated well-established associations of perceived stress with morbidity, frailty, and symptoms of depression in the BASE-II cohort studied here. In a second step, we did not find any statistically significant association of perceived stress with any of the five epigenetic clocks in multiple linear regression analyses that adjusted for covariates. Although the body of literature suggests an association between higher DNAmAA and stress or trauma during early childhood, the current study found no evidence for an association of perception of stress with DNAmAA in older people. We discuss possible reasons for the lack of associations and highlight directions for future research.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
epigenetic aging
en
dc.subject
psychological stress
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Epigenetic aging and perceived psychological stress in old age
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
410
dcterms.bibliographicCitation.doi
10.1038/s41398-022-02181-9
dcterms.bibliographicCitation.journaltitle
Translational Psychiatry
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.volume
12
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
36163242
dcterms.isPartOf.eissn
2158-3188