dc.contributor.author
Chen, Ke
dc.contributor.author
Schlagenhauf, Florian
dc.contributor.author
Sebold, Miriam
dc.contributor.author
Kuitunen-Paul, Sören
dc.contributor.author
Chen, Hao
dc.contributor.author
Huys, Quentin J. M.
dc.contributor.author
Heinz, Andreas
dc.contributor.author
Smolka, Michael N.
dc.contributor.author
Zimmermann, Ulrich S.
dc.contributor.author
Garbusow, Maria
dc.date.accessioned
2024-04-10T11:45:20Z
dc.date.available
2024-04-10T11:45:20Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/42585
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-42309
dc.description.abstract
BACKGROUND: The Pavlovian-to-instrumental transfer (PIT) paradigm measures the effects of Pavlovian conditioned cues on instrumental behavior in the laboratory. A previous study conducted by our research group observed activity in the left nucleus accumbens (NAcc) elicited by a non–drug-related PIT task across patients with alcohol dependence (AD) and healthy control subjects, and the left NAcc PIT effect differentiated patients who subsequently relapsed from those who remained abstinent. In this study, we aimed to examine whether such effects were present in a larger sample collected at a later date.
METHODS: A total of 129 recently detoxified patients with AD (21 females) and 74 healthy, age- and gender-matched control subjects (12 females) performing a PIT task during functional magnetic resonance imaging were examined. After task assessments, patients were followed for 6 months. Forty-seven patients relapsed and 37 remained abstinent.
RESULTS: We found a significant behavioral non–drug-related PIT effect and PIT-related activity in the NAcc across all participants. Moreover, subsequent relapsers showed stronger behavioral and left NAcc PIT effects than abstainers. These findings are consistent with our previous findings.
CONCLUSIONS: Behavioral non–drug-related PIT and neural PIT correlates are associated with prospective relapse risk in AD. This study replicated previous findings and provides evidence for the clinical relevance of PIT mechanisms to treatment outcome in AD. The observed difference between prospective relapsers and abstainers in the NAcc PIT effect in our study is small overall. Future studies are needed to further elucidate the mechanisms and the possible modulators of neural PIT in relapse in AD.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
alcohol dependence
en
dc.subject
nucleus accumbens
en
dc.subject
Pavlovian-to-instrumental transfer
en
dc.subject
Alcohol use disorder
en
dc.subject
Human cue-induced behavior
en
dc.subject
Nucleus accumbens
en
dc.subject
Pavlovian-to-instrumental transfer
en
dc.subject
Relapse prediction
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
The Association of Non–Drug-Related Pavlovian-to-Instrumental Transfer Effect in Nucleus Accumbens With Relapse in Alcohol Dependence: A Replication
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1016/j.biopsych.2022.09.017
dcterms.bibliographicCitation.journaltitle
Biological Psychiatry
dcterms.bibliographicCitation.number
6
dcterms.bibliographicCitation.originalpublishername
Elsevier
dcterms.bibliographicCitation.pagestart
558
dcterms.bibliographicCitation.pageend
565
dcterms.bibliographicCitation.volume
93
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.note.author
Original article first published: 2022-09-22.
en
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
38426251
dcterms.isPartOf.issn
0006-3223
dcterms.isPartOf.eissn
1873-2402