dc.contributor.author
Hoffmann, Christina
dc.contributor.author
Maglakelidze, Mariam
dc.contributor.author
Schneidemesser, Erika von
dc.contributor.author
Witt, Christian
dc.contributor.author
Hoffmann, Peter
dc.contributor.author
Butler, Tim
dc.date.accessioned
2024-02-15T13:04:50Z
dc.date.available
2024-02-15T13:04:50Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/42436
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-42160
dc.description.abstract
Background: Ambient air pollution poses a major risk for the development and aggravation of respiratory diseases. Evidence suggests that even in low-level air pollution environments there is a risk for an increase in adverse respiratory symptoms. We examined whether variations in daily air pollution levels of nitrogen dioxide, ozone, or particulate matter in Berlin, Germany were associated with hospital admissions of chronic obstructive pulmonary disease (COPD) and asthma patients in a time series analysis.
Methods: We calculated single and multi-pollutant models, investigated possible lags in effect, and analysed the influence of meteorological variables on the results. Data from January 2005 through December 2015 were used to quantify the concentration-response.
Results: The risk ratio for asthma patients to be hospitalised on the same day of NO2 exposure was 1.101 per 10 mu g/m(3) NO2 increase (95% CI: 1.013 to 1.195), for COPD patients 1.123 (95% CI: 1.081 to 1.168). Neither the exposure to ozone (95% CI: 0.904 to 1.020), PM10 (95% CI: 0.990 to 1.127), nor PM2.5 (95% CI: 0.981 to 1.148) was associated with an increased risk ratio for asthma patients to be hospitalised. Risk ratios for the hospital admission of COPD patients were also not increased due to ozone (95% CI: 0.981 to 1.033), PM10 (95% CI: 0.988 to 1.032), or PM2.5 (95% CI: 0.966 to 1.019) exposure. The presented risk ratios and confidence intervals relate to the day of exposure. We found no increased hospitalisation risks with a delayed occurrence on subsequent days.
Conclusions: A quantifiable, statistically significant increase in risk for asthma and COPD exacerbations owing to NO2 exposure at levels well below European regulatory limit values was observed.
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dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Nitrogen dioxide
en
dc.subject
Particulate matter
en
dc.subject
Hospital admission
en
dc.subject
Limit values
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Asthma and COPD exacerbation in relation to outdoor air pollution in the metropolitan area of Berlin, Germany
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
64
dcterms.bibliographicCitation.doi
10.1186/s12931-022-01983-1
dcterms.bibliographicCitation.journaltitle
Respiratory Research
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.volume
23
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
35307034
dcterms.isPartOf.eissn
1465-993X