dc.contributor.author
Boehm, Elisa
dc.contributor.author
Droessler, Linda
dc.contributor.author
Amasheh, Salah
dc.date.accessioned
2023-12-05T12:11:05Z
dc.date.available
2023-12-05T12:11:05Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/41728
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-41448
dc.description.abstract
Cannabis-based biomaterials have the potential to deliver anti-inflammatory therapeutics specifically to desired cells, tissues, and organs, enhancing drug delivery and the effectiveness of anti-inflammatory treatment while minimizing toxicity. As a major component of Cannabis, Cannabidiol (CBD) has gained major attention in recent years because of its potential therapeutic properties, e.g., for restoring a disturbed barrier resulting from inflammatory conditions. The aim of this study was to test the hypothesis that CBD has beneficial effects under normal and inflammatory conditions in the established non-transformed intestinal epithelial cell model IPEC-J2. CBD induced a significant increase in transepithelial electrical resistance (TER) values and a decrease in the paracellular permeability of [³H]-D-Mannitol, indicating a strengthening effect on the barrier. Under inflammatory conditions induced by tumor necrosis factor alpha (TNFα), CBD stabilized the TER and mitigated the increase in paracellular permeability. Additionally, CBD prevented the barrier-disrupting effects of TNFα on the distribution and localization of sealing TJ proteins. CBD also affected the expression of TNF receptors. These findings demonstrate the potential of CBD as a component of Cannabis-based biomaterials used in the development of novel therapeutic approaches against inflammatory pathogenesis.
en
dc.format.extent
12 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Epithelial barrier
en
dc.subject
Tumor necrosis factor
en
dc.subject
Tight junctions
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
dc.title
Cannabidiol attenuates inflammatory impairment of intestinal cells expanding biomaterial-based therapeutic approaches
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
100808
dcterms.bibliographicCitation.doi
10.1016/j.mtbio.2023.100808
dcterms.bibliographicCitation.journaltitle
Materials Today Bio
dcterms.bibliographicCitation.volume
23
dcterms.bibliographicCitation.url
https://doi.org/10.1016/j.mtbio.2023.100808
refubium.affiliation
Veterinärmedizin
refubium.affiliation.other
Institut für Veterinär-Physiologie
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2590-0064
refubium.resourceType.provider
WoS-Alert