dc.contributor.author
Seifert, Joshua
dc.contributor.author
Chen, Yingfu
dc.contributor.author
Schöning, Wenzel
dc.contributor.author
Mai, Knut
dc.contributor.author
Tacke, Frank
dc.contributor.author
Spranger, Joachim
dc.contributor.author
Köhrle, Josef
dc.contributor.author
Wirth, Eva Katrin
dc.date.accessioned
2023-09-22T14:47:09Z
dc.date.available
2023-09-22T14:47:09Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/40954
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-40675
dc.description.abstract
The energy homeostasis of the organism is orchestrated by a complex interplay of energy substrate shuttling, breakdown, storage, and distribution. Many of these processes are interconnected via the liver. Thyroid hormones (TH) are well known to provide signals for the regulation of energy homeostasis through direct gene regulation via their nuclear receptors acting as transcription factors. In this comprehensive review, we summarize the effects of nutritional intervention like fasting and diets on the TH system. In parallel, we detail direct effects of TH in liver metabolic pathways with regards to glucose, lipid, and cholesterol metabolism. This overview on hepatic effects of TH provides the basis for understanding the complex regulatory network and its translational potential with regards to currently discussed treatment options of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) involving TH mimetics.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
energy metabolism
en
dc.subject
lipid metabolism
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Hepatic Energy Metabolism under the Local Control of the Thyroid Hormone System
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
4861
dcterms.bibliographicCitation.doi
10.3390/ijms24054861
dcterms.bibliographicCitation.journaltitle
International Journal of Molecular Sciences
dcterms.bibliographicCitation.number
5
dcterms.bibliographicCitation.originalpublishername
MDPI
dcterms.bibliographicCitation.volume
24
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
36902289
dcterms.isPartOf.eissn
1422-0067