dc.contributor.author
Mousavi, Soraya
dc.contributor.author
Weschka, Dennis
dc.contributor.author
Bereswill, Stefan
dc.contributor.author
Heimesaat, Markus M.
dc.date.accessioned
2023-09-18T12:16:43Z
dc.date.available
2023-09-18T12:16:43Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/40894
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-40615
dc.description.abstract
Introduction: Given the worldwide increasing prevalence of human Campylobacter jejuni infections and the emergence of multi-drug resistant enteropathogenic strains, antibiotic-independent approaches applying non-toxic natural compounds for the treatment and prophylaxis of campylobacteriosis appear utmost desirable. In our placebo-controlled intervention study, we surveyed potential disease-alleviating including anti-pathogenic and immune-modulatory effects upon prophylactic oral application of lemon-essential oil (LEM-EO) and coriander-essential oil (COR-EO) in acute experimental campylobacteriosis.
Methods: Therefore, secondary abiotic IL-10(-/-) mice were orally challenged with either LEM-EO or COR-EO starting seven days prior to peroral C. jejuni infection.
Results and discussion: Six days post-infection, slightly lower pathogen loads were assessed in the colon of mice from the LEM-EO as opposed to the COR-EO cohort if compared to placebo counterparts. Prophylactic application of both EOs improved the clinical outcome of acute campylobacteriosis which was paralleled by less distinct pathogen-induced colonic epithelial cell apoptosis. Moreover, mice subjected to LEM-EO and COR-EO prophylaxis displayed lower colonic numbers of macrophages/monocytes and of T lymphocytes, respectively, whereas in both verum groups, basal IL-6 and IFN-gamma concentrations were measured in mesenteric lymph nodes on day 6 post-infection. The oral challenge with either EOs resulted in diminished secretion of distinct pro-inflammatory mediators in the kidney as well as serum samples derived from the infected mice. In conclusion, the results from our preclinical in vivo study provide evidence that LEM-EO and COR-EO constitute promising prophylactic measures to prevent severe campylobacteriosis which may help to reduce the risk for development of post-infectious sequelae in C. jejuni infected individuals.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
lemon essential oil (citrus Limon l.)
en
dc.subject
coriander essential oil
en
dc.subject
Campylobacter jejuni
en
dc.subject
secondary abiotic IL-10-/- mice
en
dc.subject
campylobacteriosis model
en
dc.subject
host-pathogen interaction
en
dc.subject
immune-modulatory effects
en
dc.subject
natural antibiotics-independent compounds
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Disease alleviating effects following prophylactic lemon and coriander essential oil treatment in mice with acute campylobacteriosis
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1154407
dcterms.bibliographicCitation.doi
10.3389/fmicb.2023.1154407
dcterms.bibliographicCitation.journaltitle
Frontiers in Microbiology
dcterms.bibliographicCitation.originalpublishername
Frontiers Media SA
dcterms.bibliographicCitation.volume
14
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
37065112
dcterms.isPartOf.eissn
1664-302X