dc.contributor.author
Fischer-Tenhagen, Carola
dc.contributor.author
Bohm, Detlev
dc.contributor.author
Finnah, Anke
dc.contributor.author
Arlt, Sebastian Patrick
dc.contributor.author
Schlesinger, Samira
dc.contributor.author
Borchardt, Stefan
dc.contributor.author
Sutter, Franziska
dc.contributor.author
Tippenhauer, Christie
dc.contributor.author
Heuwieser, Wolfgang
dc.contributor.author
Venjakob, Peter
dc.date.accessioned
2023-08-21T08:43:26Z
dc.date.available
2023-08-21T08:43:26Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/40558
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-40278
dc.description.abstract
Dry cow treatment with an intramammary antibiotic is recommended to reduce the risk of mastitis at the beginning of the next lactation. The dry period may be shortened unintentionally, affecting antibiotic residue depletion and the time when residues reach concentrations below the maximum residue limit (MRL). The objective of this study was to evaluate residue depletion in milk after dry cow treatment with cloxacillin, considering dry periods of 14 (G14d), 21 (G21d), and 28 d (G28d). Overall, fifteen cows with 60 udder quarters were included in the study. For each cow, three of the udder quarters were treated with 1000 mg cloxacillin benzathine (2:1) on d 252, d 259, and d 266 of gestation; one quarter was left untreated. Milk samples were drawn until 20 DIM and milk composition, somatic cell count and cloxacillin residues were analyzed. The HPLC-MS/MS revealed different excretion kinetics for the compounds cloxacillin and cloxacillin benzathine (1:1). All cows showed a cloxacillin and cloxacillin benzathine (1:1) concentration below the MRL of 30 µg/kg after 5 d. In the udder quarters of G21d and G28d, the cloxacillin concentration was already below the MRL at first milking after calving. The cloxacillin benzathine (1:1) concentration in the milk of G28d, G21d, and G14d fell below 30 µg/kg on the 5th, 3rd, and 5th DIM, respectively. Shortening the dry period affects residue depletion after dry cow treatment with cloxacillin. The risk of exceeding the MRL, however, seems low, even with dry periods shorter than 14 d.
en
dc.format.extent
12 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
antibiotic residues
en
dc.subject
short dry period
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::636 Viehwirtschaft
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik
dc.title
Residue concentrations of cloxacillin in milk after intramammary dry cow treatment considering dry period length
dc.type
Wissenschaftlicher Artikel
dc.identifier.sepid
94748
dcterms.bibliographicCitation.articlenumber
Artikel 2558
dcterms.bibliographicCitation.doi
10.3390/ani13162558
dcterms.bibliographicCitation.journaltitle
Animals
dcterms.bibliographicCitation.originalpublishername
MDPI
dcterms.bibliographicCitation.originalpublisherplace
Basel
dcterms.bibliographicCitation.volume
13
dcterms.bibliographicCitation.url
http://dx.doi.org/10.3390/ani13162558
refubium.affiliation
Veterinärmedizin
refubium.affiliation.other
Tierklinik für Fortpflanzung
refubium.note.author
Die Publikation wurde aus Open Access Publikationsgeldern der Freien Universität Berlin gefördert.
de
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2076-2615