dc.contributor.author
Wang, Ting
dc.date.accessioned
2023-08-08T08:52:04Z
dc.date.available
2023-08-08T08:52:04Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/40288
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-40009
dc.description.abstract
Nanosuspension technology is a strategy to increase the bioavailability of poorly
soluble drugs and has been used for various routes of drug administration. Nanocrystals
consist of pure drug, thus allowing the administration of a high drug dose in a small
volume. This is advantageous for topical administration to increase the concentration
gradient for the drug uptake into the skin. Moreover, the nm size of the drug (< 1μm)
allows improved skin penetration and enhanced drug delivery to the target site.
Nanosuspensions can be used as prepared or be loaded into semisolid vehicles. There
are some challenges, which need to be solved. Stabilizers are unavoidable for aqueous
nanosuspensions. However, stabilizers can also be a limiting factor for stability, e.g.,
during freeze-thaw cycling or sterilization. In addition, stabilizers might interact with
the excipient in semisolid dosage forms, resulting in a different performance of the
nanocrystals. The nanocrystal stability upon topical administration is also still an open
question. Therefore, a systematic investigation of nanocrystal-loaded topical
formulations was performed upon preparation, incorporation into semisolid vehicles
and administration.
en
dc.format.extent
IV, 133 Seiten
dc.rights.uri
http://www.fu-berlin.de/sites/refubium/rechtliches/Nutzungsbedingungen
dc.subject
Nanocrystals
en
dc.subject
crystal growth
en
dc.subject.ddc
500 Natural sciences and mathematics::540 Chemistry and allied sciences::540 Chemistry and allied sciences
dc.subject.ddc
500 Natural sciences and mathematics::540 Chemistry and allied sciences::542 Techniques, equipment, materials
dc.title
Development and evaluation of nanocrystal formulations and their incorporation into topical semisolid vehicles
dc.contributor.gender
female
dc.contributor.firstReferee
Bodmeier, Roland
dc.contributor.furtherReferee
Maincent, Philippe
dc.date.accepted
2023-07-03
dc.identifier.urn
urn:nbn:de:kobv:188-refubium-40288-7
refubium.affiliation
Biologie, Chemie, Pharmazie
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free
dcterms.accessRights.openaire
open access
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accept