dc.contributor.author
Doerrfuss, Jakob I.
dc.contributor.author
Kowski, Alexander B.
dc.contributor.author
Holtkamp, Martin
dc.contributor.author
Thinius, Moritz
dc.contributor.author
Leithner, Christoph
dc.contributor.author
Storm, Christian
dc.date.accessioned
2023-07-25T12:06:38Z
dc.date.available
2023-07-25T12:06:38Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/40233
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-39953
dc.description.abstract
Background: Electroencephalography (EEG) significantly contributes to the neuroprognostication after resuscitation from cardiac arrest. Recent studies suggest that the prognostic value of EEG is highest for continuous recording within the first days after cardiac arrest. Early continuous EEG, however, is not available in all hospitals. In this observational study, we sought to evaluate the predictive value of a 'late' EEG recording 5-14 days after cardiac arrest without sedatives.
Methods: We retrospectively analyzed EEG data in consecutive adult patients treated at the medical intensive care units (ICU) of the Charite-Universitatsmedizin Berlin. Outcome was assessed as cerebral performance category (CPC) at discharge from ICU, with an unfavorable outcome being defined as CPC 4 and 5.
Results: In 187 patients, a 'late' EEG recording was performed. Of these patients, 127 were without continuous administration of sedative agents for at least 24 h before the EEG recording. In this patient group, a continuously suppressed background activity < 10 mu V predicted an unfavorable outcome with a sensitivity of 31% (95% confidence interval (CI) 20-45) and a specificity of 99% (95% CI 91-100). In patients with suppressed background activity and generalized periodic discharges, sensitivity was 15% (95% CI 7-27) and specificity was 100% (95% CI 94-100). GPDs on unsuppressed background activity were associated with a sensitivity of 42% (95% CI 29-46) and a specificity of 92% (95% CI 82-97).
Conclusions: A 'late' EEG performed 5 to 14 days after resuscitation from cardiac arrest can aide in prognosticating functional outcome. A suppressed EEG background activity in this time period indicates poor outcome.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Predictive value of tests
en
dc.subject
Resuscitation
en
dc.subject
Targeted temperature management
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Prognostic value of ‘late’ electroencephalography recordings in patients with cardiopulmonal resuscitation after cardiac arrest
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1007/s00415-021-10549-y
dcterms.bibliographicCitation.journaltitle
Journal of Neurology
dcterms.bibliographicCitation.number
11
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.pagestart
4248
dcterms.bibliographicCitation.pageend
4257
dcterms.bibliographicCitation.volume
268
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33871711
dcterms.isPartOf.issn
0340-5354
dcterms.isPartOf.eissn
1432-1459