dc.contributor.author
Alfaar, Ahmad Samir
dc.contributor.author
Saad, Anas
dc.contributor.author
Wiedemann, Peter
dc.contributor.author
Rehak, Matus
dc.date.accessioned
2023-06-23T10:47:37Z
dc.date.available
2023-06-23T10:47:37Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/39887
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-39607
dc.description.abstract
Purpose: To calculate the overall incidence of uveal melanoma in Germany and to compare incidences in different German states. In addition, we computed the overall and cancer-specific survival rates nationwide.
Methods: Incidence data for the period between 2009 and 2015, covering the entire German population, was collected through the German Center for Cancer Registry. ICD-O-3 topography codes C69.3-C69.4 and histology codes for melanoma subtypes were used to collect the incidence data. Confidence Intervals with a level of 95% (95% CI) were calculated for rates. Survival was calculated using the Kaplan–Meier. The log-rank test was used for survival comparisons.
Results: This study comprised 3654 patients with uveal melanomas, including 467 (12.8%) with iridial and ciliary body tumors. The overall age-standardized incidence rate (ASIR) was 6.41 person per million. Generally, the ASIR was higher in males than females (6.67 (95% CI 6.37–6.98) vs. 6.16 (95% CI 5.88–6.45 per million). Higher crude incidence rates were noted in the northeastern states (12.5 per million (95% CI 10.5–14.7) in Mecklenburg-Vorpommern) compared with the southwestern states (2.1 per million (95% CI 1.7–2.6) in Hessen). The 5-year overall survival stood at 47%, while the cancer-specific survival stood at 84%. Multivariate analysis showed that women, younger patients, and patients living in Berlin achieved significantly higher overall survival.
Conclusion: Overall ASIR of uveal melanoma in Germany indicates that the disease is more common in males and that it follows the same geographical distribution previously noted in central European countries, with the highest incidence in northern parts of Germany.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Ciliary body
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
The epidemiology of uveal melanoma in Germany: a nationwide report of incidence and survival between 2009 and 2015
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1007/s00417-021-05317-7
dcterms.bibliographicCitation.journaltitle
Graefe's Archive for Clinical and Experimental Ophthalmology
dcterms.bibliographicCitation.number
5
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.pagestart
1723
dcterms.bibliographicCitation.pageend
1731
dcterms.bibliographicCitation.volume
260
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
34605956
dcterms.isPartOf.issn
0721-832X
dcterms.isPartOf.eissn
1435-702X