dc.contributor.author
Grosse, Frederik
dc.contributor.author
Rueckriegel, Stefan Mark
dc.contributor.author
Thomale, Ulrich-Wilhelm
dc.contributor.author
Hernáiz Driever, Pablo
dc.date.accessioned
2023-06-13T11:22:00Z
dc.date.available
2023-06-13T11:22:00Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/39812
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-39532
dc.description.abstract
Purpose: Diaschisis of cerebrocerebellar loops contributes to cognitive and motor deficits in pediatric cerebellar brain tumor survivors. We used a cerebellar white matter atlas and hypothesized that lesion symptom mapping may reveal the critical lesions of cerebellar tracts.
Methods: We examined 31 long-term survivors of pediatric posterior fossa tumors (13 pilocytic astrocytoma, 18 medulloblastoma). Patients underwent neuronal imaging, examination for ataxia, fine motor and cognitive function, planning abilities, and executive function. Individual consolidated cerebellar lesions were drawn manually onto patients' individual MRI and normalized into Montreal Neurologic Institute (MNI) space for further analysis with voxel-based lesion symptom mapping.
Results: Lesion symptom mapping linked deficits of motor function to the superior cerebellar peduncle (SCP), deep cerebellar nuclei (interposed nucleus (IN), fastigial nucleus (FN), ventromedial dentate nucleus (DN)), and inferior vermis (VIIIa, VIIIb, IX, X). Statistical maps of deficits of intelligence and executive function mapped with minor variations to the same cerebellar structures.
Conclusion: We identified lesions to the SCP next to deep cerebellar nuclei as critical for limiting both motor and cognitive function in pediatric cerebellar tumor survivors. Future strategies safeguarding motor and cognitive function will have to identify patients preoperatively at risk for damage to these critical structures and adapt multimodal therapeutic options accordingly.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Lesion symptom mapping
en
dc.subject
Cognitive function
en
dc.subject
Executive function
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Mapping of long-term cognitive and motor deficits in pediatric cerebellar brain tumor survivors into a cerebellar white matter atlas
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1007/s00381-021-05244-2
dcterms.bibliographicCitation.journaltitle
Child's Nervous System
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.pagestart
2787
dcterms.bibliographicCitation.pageend
2797
dcterms.bibliographicCitation.volume
37
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
34355257
dcterms.isPartOf.issn
0256-7040
dcterms.isPartOf.eissn
1433-0350