dc.contributor.author
Appunni, Sandeep
dc.contributor.author
Rubens, Muni
dc.contributor.author
Ramamoorthy, Venkataraghavan
dc.contributor.author
Saxena, Anshul
dc.contributor.author
Tonse, Raees
dc.contributor.author
Veledar, Emir
dc.contributor.author
McGranaghan, Peter
dc.date.accessioned
2023-03-17T14:01:31Z
dc.date.available
2023-03-17T14:01:31Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/38441
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-38159
dc.description.abstract
Purpose: Many smaller studies have previously shown a significant association between thyroid autoantibody induced hypothyroidism and lower serum vitamin D levels. However, these finding have not been confirmed by large-scale studies. In this study, we evaluated the relationship between hypothyroidism and vitamin D levels using a large population-based data.
Methods: For this study, we used National Health and Nutrition Examination Survey (NHANES) during the years 2007-2012. We categorized participants into three clinically relevant categories based on vitamin D levels: optimal, intermediate and deficient. Participants were also split into hypothyroid and hyperthyroid. Weighted multivariable logistic regression analyses were used to calculate the odds of being hypothyroid based on vitamin D status.
Results: A total of 7943 participants were included in this study, of which 614 (7.7%) were having hypothyroidism. Nearly 25.6% of hypothyroid patients had vitamin D deficiency, compared to 20.6% among normal controls. Adjusted logistic regression analyses showed that the odds of developing hypothyroidism were significantly higher among patients with intermediate (adjusted odds ratio [aOR], 1.7, 95% CI: 1.5-1.8) and deficient levels of vitamin D (aOR, 1.6, 95% CI: 1.4-1.9).
Conclusion: Low vitamin D levels are associated with autoimmune hypothyroidism. Healthcare initiatives such as mass vitamin D deficiency screening among at-risk population could significantly decrease the risk for hypothyroidism in the long-term.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Hypothyroidism
en
dc.subject
Low vitamin D
en
dc.subject
Thyroid peroxidase
en
dc.subject
Thyroglobulin
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Association between vitamin D deficiency and hypothyroidism: results from the National Health and Nutrition Examination Survey (NHANES) 2007–2012
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
224
dcterms.bibliographicCitation.doi
10.1186/s12902-021-00897-1
dcterms.bibliographicCitation.journaltitle
BMC Endocrine Disorders
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.volume
21
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
34772378
dcterms.isPartOf.eissn
1472-6823