dc.contributor.author
Danyel, Leon Alexander
dc.contributor.author
Miszczuk, Milena Anna
dc.contributor.author
Villringer, Kersten
dc.contributor.author
Bohner, Georg
dc.contributor.author
Siebert, Eberhard
dc.date.accessioned
2023-03-07T13:11:29Z
dc.date.available
2023-03-07T13:11:29Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/38223
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-37941
dc.description.abstract
This study sought to investigate the occurrence of retinal diffusion restrictions (RDR) in branch retinal arteriolar occlusion (BRAO) using standard brain diffusion-weighted imaging (DWI). Two radiologists assessed DWI MRI scans of BRAO patients for RDR in a retrospective cohort study. Inter- and intrarater reliability were calculated using Kappa statistics. Detection rates of RDR were compared among MRI scans with varying field strength, sequence type and onset-to-DWI time intervals. 85 BRAO patients (63.1 +/- 16.5 years) and 89 DWI scans were evaluated. Overall sensitivity of RDR in BRAO was 46.1% with visually correlating low ADC signal in 56.1% of cases. Localization of RDR matched distribution of fundoscopic retinal edema in 85% of patients. Inter- and intra-rater agreement for RDR in BRAO was kappa(inter) = 0.64 (95% CI 0.48-0.80) and kappa(intra) = 0.87 (95% CI 0.76-0.96), respectively. RDR detection rate tended to be higher for 3T, when compared to 1.5T MRI scans (53.7% vs. 34.3%%; p = 0.07). RDR were identified within 24 h up to 2 weeks after onset of visual impairment. RDR in BRAO can be observed by means of standard stroke DWI in a substantial proportion of cases, although sensitivity and interrater reliability were lower than previously reported for complete central retinal artery occlusion.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
retinal diffusion restrictions (RDR)
en
dc.subject
branch retinal arteriolar occlusion (BRAO)
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Retinal diffusion restrictions in acute branch retinal arteriolar occlusion
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
20538
dcterms.bibliographicCitation.doi
10.1038/s41598-021-00127-7
dcterms.bibliographicCitation.journaltitle
Scientific Reports
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.volume
11
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
34654843
dcterms.isPartOf.eissn
2045-2322