dc.contributor.author
König, Maximilian
dc.contributor.author
Buchmann, Nikolaus
dc.contributor.author
Seeland, Ute
dc.contributor.author
Spira, Dominik
dc.contributor.author
Steinhagen-Thiessen, Elisabeth
dc.contributor.author
Demuth, Ilja
dc.date.accessioned
2023-02-24T14:03:15Z
dc.date.available
2023-02-24T14:03:15Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/38108
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-37821
dc.description.abstract
Low handgrip strength and increased arterial stiffness are both associated with poor health outcomes, but evidence on the relationship between handgrip strength and arterial stiffness is limited. In this cross-sectional analysis of combined baseline datasets from the LipidCardio and Berlin Aging Study II cohorts we aimed to examine whether handgrip strength (HGS) is associated with arterial stiffness. 1511 participants with a median age of 68.56 (IQR 63.13-73.08) years were included. Arterial stiffness was assessed by aortal pulse wave velocity (PWV) with the Mobil-O-Graph device. Handgrip strength was assessed with a handheld dynamometer.The mean HGS was 39.05 +/- 9.07 kg in men and 26.20 +/- 7.47 kg in women. According to multivariable linear regression analysis per 5 kg decrease in handgrip strength there was a mean increase in PWV of 0.08 m/s after adjustment for the confounders age, sex, coronary artery disease, systolic blood pressure, body mass index, cohort, and smoking. Thus, there was evidence that low handgrip strength and increased arterial stiffness go hand in hand. Arterial stiffness can possibly create the missing link between low handgrip strength and increased cardiovascular morbidity and mortality. Causality and direction of causality remain to be determined.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
muscle strength
en
dc.subject
arterial stiffness
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Low muscle strength and increased arterial stiffness go hand in hand
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
2906
dcterms.bibliographicCitation.doi
10.1038/s41598-021-81084-z
dcterms.bibliographicCitation.journaltitle
Scientific Reports
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.volume
11
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33536474
dcterms.isPartOf.eissn
2045-2322