dc.contributor.author
Bock-Bierbaum, Tobias
dc.contributor.author
Funck, Kathrin
dc.contributor.author
Wollweber, Florian
dc.contributor.author
Lisicki, Elisa
dc.contributor.author
Malsburg, Karina von der
dc.contributor.author
Malsburg, Alexander von der
dc.contributor.author
Laborenz, Janina
dc.contributor.author
Noel, Jeffrey K.
dc.contributor.author
Hessenberger, Manuel
dc.contributor.author
Daumke, Oliver
dc.date.accessioned
2023-01-26T12:42:03Z
dc.date.available
2023-01-26T12:42:03Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/37766
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-37479
dc.description.abstract
Mitochondrial cristae membranes are the oxidative phosphorylation sites in cells. Crista junctions (CJs) form the highly curved neck regions of cristae and are thought to function as selective entry gates into the cristae space. Little is known about how CJs are generated and maintained. We show that the central coiled-coil (CC) domain of the mitochondrial contact site and cristae organizing system subunit Mic60 forms an elongated, bow tie–shaped tetrameric assembly. Mic19 promotes Mic60 tetramerization via a conserved interface between the Mic60 mitofilin and Mic19 CHCH (CC-helix-CC-helix) domains. Dimerization of mitofilin domains exposes a crescent-shaped membrane-binding site with convex curvature tailored to interact with the curved CJ neck. Our study suggests that the Mic60-Mic19 subcomplex traverses CJs as a molecular strut, thereby controlling CJ architecture and function.
en
dc.format.extent
13 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject
mitochondrial cristae membranes
en
dc.subject
cristae space
en
dc.subject
crista junctions
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.title
Structural insights into crista junction formation by the Mic60-Mic19 complex
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1126/sciadv.abo4946
dcterms.bibliographicCitation.journaltitle
Science Advances
dcterms.bibliographicCitation.number
35
dcterms.bibliographicCitation.volume
8
dcterms.bibliographicCitation.url
https://doi.org/10.1126/sciadv.abo4946
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2375-2548
refubium.resourceType.provider
WoS-Alert