dc.contributor.author
Fuhrmann, Laura
dc.contributor.author
Zentek, Jürgen
dc.contributor.author
Vahjen, Wilfried
dc.contributor.author
Günther, Ronald
dc.contributor.author
Saliu, Eva-Maria
dc.date.accessioned
2023-01-06T12:10:45Z
dc.date.available
2023-01-06T12:10:45Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/37482
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-37195
dc.description.abstract
Antibiotic resistance poses a risk for human and animal health, leading to a growing demand for effective alternatives. Combining nutritional tools and parent stock vaccination could be an approach to achieve sufficient protection against bacterial infections in poultry. In an Escherichia coli O1/O18 challenge trial, we investigated the protective effects of feeding diets containing Enterococcus faecium DSM 7134 and fructooligosaccharides (FOS) combined with specific parent stock vaccination in 225 ROSS 308 broilers. Data on performance parameters, intestinal microbial composition and metabolites, and antibiotic resistance genes (sul1-3, dhfr1a, SHV-12) were obtained. E. faecium and FOS combined with parent stock vaccination led to the highest body weights, which were significantly higher than those of controls throughout the experiment and decreased the relative abundance of Proteobacteria in the crop digesta compared to that in the positive control. However, cumulative feed conversation remained unaffected by the strategies. Birds receiving the pre-/probiotic combination showed lower cecal pH levels and higher crop L-lactate concentrations than the controls, whereas copy numbers of dhfr1a (trimethoprim resistance) and SHV-12 (extended-spectrum beta-lactamase) genes were only decreased in broilers from vaccinated hens compared to those in the challenged control. In conclusion, prophylactic administration of E. faecium and FOS in combination with parent stock vaccination can have complementary effects by improving broiler weight gain and stimulating intestinal bacterial metabolism, which may be beneficial for maintaining gut health in terms of Escherichia coli infection.
en
dc.format.extent
20 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Enterococcus faecium
en
dc.subject
direct fed microbials
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
dc.title
Effects of a Specific Pre- and Probiotic Combination and Parent Stock Vaccination on Performance and Bacterial Communities in Broilers Challenged with a Multidrug-Resistant Escherichia coli
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1703
dcterms.bibliographicCitation.doi
10.3390/antibiotics11121703
dcterms.bibliographicCitation.journaltitle
Antibiotics
dcterms.bibliographicCitation.number
12
dcterms.bibliographicCitation.originalpublishername
MDPI
dcterms.bibliographicCitation.volume
11
dcterms.bibliographicCitation.url
https://doi.org/10.3390/antibiotics11121703
refubium.affiliation
Veterinärmedizin
refubium.affiliation.other
Institut für Tierernährung
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2079-6382