dc.contributor.author
Schrezenmeier, Eva
dc.contributor.author
Lehner, Lukas J.
dc.contributor.author
Merkel, Marina
dc.contributor.author
Mayrdorfer, Manuel
dc.contributor.author
Duettmann, Wiebke
dc.contributor.author
Naik, Marcel G.
dc.contributor.author
Fröhlich, Felix
dc.contributor.author
Liefeldt, Lutz
dc.contributor.author
Pigorsch, Mareen
dc.contributor.author
Friedersdorff, Frank
dc.contributor.author
Schmidt, Danilo
dc.contributor.author
Niemann, Matthias
dc.contributor.author
Lachmann, Nils
dc.contributor.author
Budde, Klemens
dc.contributor.author
Halleck, Fabian
dc.date.accessioned
2022-12-02T13:29:10Z
dc.date.available
2022-12-02T13:29:10Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/37147
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-36860
dc.description.abstract
The number of patients returning to dialysis after graft failure increases. Surprisingly, little is known about the clinical and immunological outcomes of this cohort. We retrospectively analyzed 254 patients after kidney allograft loss between 1997 and 2017 and report clinical outcomes such as mortality, relisting, retransplantations, transplant nephrectomies, and immunization status. Of the 254 patients, 49% had died 5 years after graft loss, while 27% were relisted, 14% were on dialysis and not relisted, and only 11% were retransplanted 5 years after graft loss. In the complete observational period, 111/254 (43.7%) patients were relisted. Of these, 72.1% of patients were under 55 years of age at time of graft loss and only 13.5% of patients were >= 65 years. Age at graft loss was associated with relisting in a logistic regression analysis. In the complete observational period, 42 patients (16.5%) were retransplanted. Only 4 of those (9.5%) were >= 65 years at time of graft loss. Nephrectomy had no impact on survival, relisting, or development of dnDSA. Patients after allograft loss have a high overall mortality. Immunization contributes to long waiting times. Only a very limited number of patients are retransplanted especially when >= 65 years at time of graft loss.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
immunization
en
dc.subject
PIRCHE score
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
What happens after graft loss? A large, long‐term, single‐center observation
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1111/tri.13834
dcterms.bibliographicCitation.journaltitle
Transplant International
dcterms.bibliographicCitation.number
4
dcterms.bibliographicCitation.originalpublishername
Frontiers Media SA
dcterms.bibliographicCitation.pagestart
732
dcterms.bibliographicCitation.pageend
742
dcterms.bibliographicCitation.volume
34
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33527467
dcterms.isPartOf.issn
0934-0874
dcterms.isPartOf.eissn
1432-2277