dc.contributor.author
Bizjak, Mojca
dc.contributor.author
Košnik, Mitja
dc.contributor.author
Dinevski, Dejan
dc.contributor.author
Thomsen, Simon Francis
dc.contributor.author
Fomina, Daria
dc.contributor.author
Borzova, Elena
dc.contributor.author
Kulthanan, Kanokvalai
dc.contributor.author
Meshkova, Raisa
dc.contributor.author
Ahsan, Dalia Melina
dc.contributor.author
Al‐Ahmad, Mona
dc.contributor.author
Altrichter, Sabine
dc.contributor.author
Bauer, Andrea
dc.contributor.author
Brockstädt, Maxi
dc.contributor.author
Costa, Célia
dc.contributor.author
Demir, Semra
dc.contributor.author
Fachini Criado, Roberta
dc.contributor.author
Ensina, Luis Felipe
dc.contributor.author
Gelincik, Asli
dc.contributor.author
Giménez‐Arnau, Ana Maria
dc.contributor.author
Gonçalo, Margarida
dc.contributor.author
Gotua, Maia
dc.contributor.author
Holm, Jesper Grønlund
dc.contributor.author
Inomata, Naoko
dc.contributor.author
Kasperska‐Zajac, Alicja
dc.contributor.author
Khoshkhui, Maryam
dc.contributor.author
Klyucharova, Aliya
dc.contributor.author
Kocatürk, Emek
dc.contributor.author
Lu, Rongbiao
dc.contributor.author
Makris, Michael
dc.contributor.author
Maltseva, Natalya
dc.contributor.author
Miljković, Jovan
dc.contributor.author
Pasali, Maria
dc.contributor.author
Paulino, Marisa
dc.contributor.author
Pesqué, David
dc.contributor.author
Peter, Jonny
dc.contributor.author
Ramón, German Dario
dc.contributor.author
Ritchie, Carla
dc.contributor.author
Rodrigues Valle, Solange Oliveira
dc.contributor.author
Rudenko, Michael
dc.contributor.author
Sikora, Agnieszka
dc.contributor.author
de Souza Lima, Eduardo M.
dc.contributor.author
Wagner, Nicola
dc.contributor.author
Xepapadaki, Paraskevi
dc.contributor.author
Xue, Xiaoyang
dc.contributor.author
Zhao, Zuotao
dc.contributor.author
Terhorst‐Molawi, Dorothea
dc.contributor.author
Maurer, Marcus
dc.date.accessioned
2022-11-22T13:02:39Z
dc.date.available
2022-11-22T13:02:39Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/36981
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-36694
dc.description.abstract
Background: Cold urticaria (ColdU), that is, the occurrence of wheals or angioedema in response to cold exposure, is classified into typical and atypical forms. The diagnosis of typical ColdU relies on whealing in response to local cold stimulation testing (CST). It can also manifest with cold-induced anaphylaxis (ColdA). We aimed to determine risk factors for ColdA in typical ColdU.
Methods: An international, cross-sectional study COLD-CE was carried out at 32 urticaria centers of reference and excellence (UCAREs). Detailed history was taken and CST with an ice cube and/or TempTest® performed. ColdA was defined as an acute cold-induced involvement of the skin and/or visible mucosal tissue and at least one of: cardiovascular manifestations, difficulty breathing, or gastrointestinal symptoms.
Results: Of 551 ColdU patients, 75% (n = 412) had a positive CST and ColdA occurred in 37% (n = 151) of the latter. Cold-induced generalized wheals, angioedema, acral swelling, oropharyngeal/laryngeal symptoms, and itch of earlobes were identified as signs/symptoms of severe disease. ColdA was most commonly provoked by complete cold water immersion and ColdA caused by cold air was more common in countries with a warmer climate. Ten percent (n = 40) of typical ColdU patients had a concomitant chronic spontaneous urticaria (CSU). They had a lower frequency of ColdA than those without CSU (4% vs. 39%, p = .003). We identified the following risk factors for cardiovascular manifestations: previous systemic reaction to a Hymenoptera sting, angioedema, oropharyngeal/laryngeal symptoms, and itchy earlobes.
Conclusion: ColdA is common in typical ColdU. High-risk patients require education about their condition and how to use an adrenaline autoinjector.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject
adrenaline autoinjector
en
dc.subject
cold urticaria
en
dc.subject
risk factors
en
dc.subject
systemic reactions
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Risk factors for systemic reactions in typical cold urticaria: Results from the COLD‐CE study
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1111/all.15194
dcterms.bibliographicCitation.journaltitle
Allergy
dcterms.bibliographicCitation.number
7
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.pagestart
2185
dcterms.bibliographicCitation.pageend
2199
dcterms.bibliographicCitation.volume
77
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
34862605
dcterms.isPartOf.issn
0105-4538
dcterms.isPartOf.eissn
1398-9995