dc.contributor.author
Wesarg, Christiane
dc.contributor.author
Veer, Ilya M.
dc.contributor.author
Oei, Nicole Y. L.
dc.contributor.author
Daedelow, Laura S.
dc.contributor.author
Lett, Tristram A.
dc.contributor.author
Banaschewski, Tobias
dc.contributor.author
Barker, Gareth J.
dc.contributor.author
Bokde, Arun L.W.
dc.contributor.author
Quinlan, Erin Burke
dc.contributor.author
Desrivières, Sylvane
dc.contributor.author
Flor, Herta
dc.contributor.author
Grigis, Antoine
dc.contributor.author
Garavan, Hugh
dc.contributor.author
Brühl, Rüdiger
dc.contributor.author
Martinot, Jean‐Luc
dc.contributor.author
Artiges, Eric
dc.contributor.author
Nees, Frauke
dc.contributor.author
Orfanos, Dimitri Papadopoulos
dc.contributor.author
Poustka, Luise
dc.contributor.author
Hohmann, Sarah
dc.contributor.author
Fröhner, Juliane H.
dc.contributor.author
Smolka, Michael N.
dc.contributor.author
Whelan, Robert
dc.contributor.author
Schumann, Gunter
dc.contributor.author
Heinz, Andreas
dc.contributor.author
Walter, Henrik
dc.contributor.author
IMAGEN Consortium
dc.date.accessioned
2022-11-04T15:37:45Z
dc.date.available
2022-11-04T15:37:45Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/36718
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-36431
dc.description.abstract
Extensive research has demonstrated that rs1360780, a common single nucleotide polymorphism within the FKBP5 gene, interacts with early-life stress in predicting psychopathology. Previous results suggest that carriers of the TT genotype of rs1360780 who were exposed to child abuse show differences in structure and functional activation of emotion-processing brain areas belonging to the salience network. Extending these findings on intermediate phenotypes of psychopathology, we examined if the interaction between rs1360780 and child abuse predicts resting-state functional connectivity (rsFC) between the amygdala and other areas of the salience network. We analyzed data of young European adults from the general population (N = 774; mean age = 18.76 years) who took part in the IMAGEN study. In the absence of main effects of genotype and abuse, a significant interaction effect was observed for rsFC between the right centromedial amygdala and right posterior insula (p < .025, FWE-corrected), which was driven by stronger rsFC in TT allele carriers with a history of abuse. Our results suggest that the TT genotype of rs1360780 may render individuals with a history of abuse more vulnerable to functional changes in communication between brain areas processing emotions and bodily sensations, which could underlie or increase the risk for psychopathology.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
gene–environment interaction
en
dc.subject
resting-state functional connectivity
en
dc.subject
salience network
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
The interaction of child abuse and rs1360780 of the FKBP5 gene is associated with amygdala resting‐state functional connectivity in young adults
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1002/hbm.25433
dcterms.bibliographicCitation.journaltitle
Human Brain Mapping
dcterms.bibliographicCitation.number
10
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.pagestart
3269
dcterms.bibliographicCitation.pageend
3281
dcterms.bibliographicCitation.volume
42
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33818852
dcterms.isPartOf.issn
1065-9471
dcterms.isPartOf.eissn
1097-0193