dc.contributor.author
Ziegeler, Katharina
dc.contributor.author
Richter, Sophia-Theresa
dc.contributor.author
Hermann, Sandra
dc.contributor.author
Hermann, Kay Geert A.
dc.contributor.author
Hamm, Bernd
dc.contributor.author
Diekhoff, Torsten
dc.date.accessioned
2022-09-21T10:01:58Z
dc.date.available
2022-09-21T10:01:58Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/36404
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-36120
dc.description.abstract
Objectives: To evaluate differences in collagen density as detected by dual-energy computed tomography (DECT) of wrist ligaments between patients with calcium pyrophosphate-dihydrate deposition disease (CPPD) and a control group in order to gain insight into changes of the extracellular matrix in response to crystal deposition.
Materials and methods: This retrospective study included 28 patients (18 with CPPD, 10 controls) who underwent DECT of the wrist. Collagen density maps were reconstructed from the DECT datasets and used to measure densities in regions of interest (ROIs) placed in the scapholunate (SL) ligament (dorsal, palmar, proximal), lunotriquetral (LT) ligament, and extensor carpi radialis (ECR) tendon, (n = 260 measurements). The presence of calcifications on standard CT images in these regions was assessed by a blinded reader. Densities were compared with nonparametric tests, and linear regression analysis was performed to investigate the impact of age, sex, and CT- detected calcium deposition on collagen density.
Results: Collagen density in the SL ligament was significantly higher in CPPD patients than in controls (overall mean: 265.4 ± 32.1 HU vs. 196.3 ± 33.8 HU; p < 0.001). In the ECR tendon, collagen densities did not differ significantly (p = 0.672): 161.3 ± 20.1 HU in CPPD vs. 163.6 ± 12.0 HU in controls. Regression analysis showed that diagnosis, but not age or calcification, had a significant impact on collagen density.
Conclusion: Collagen density of the SL ligament is significantly higher in CPPD patients than in control patients. Further research is needed to understand these changes in the extracellular matrix of ligaments in CPPD.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Chondrocalcinosis
en
dc.subject
Dual-energy computed tomography
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Dual-energy CT collagen density mapping of wrist ligaments reveals tissue remodeling in CPPD patients: first results from a clinical cohort
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1007/s00256-020-03580-z
dcterms.bibliographicCitation.journaltitle
Skeletal Radiology
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.pagestart
417
dcterms.bibliographicCitation.pageend
423
dcterms.bibliographicCitation.volume
50
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32803375
dcterms.isPartOf.issn
0364-2348
dcterms.isPartOf.eissn
1432-2161