dc.contributor.author
Ruscher, Victoria
dc.contributor.author
Lieber, Sascha
dc.contributor.author
Kühl, Jörn-Sven
dc.contributor.author
Schulte, Johannes
dc.contributor.author
Blankenburg, Markus
dc.contributor.author
Reindl, Tobias
dc.contributor.author
Hernáiz Driever, Pablo
dc.date.accessioned
2022-09-09T10:13:05Z
dc.date.available
2022-09-09T10:13:05Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/36245
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-35961
dc.description.abstract
Purpose: We aimed at describing for the first time peripheral small-fiber neurotoxicity and pain sensitization in survivors of pediatric acute lymphoblastic leukemia after stem cell transplantation (SCT).
Methods: In a cross-sectional, retrospective, single-center study, we assessed 25 relapse-free long-term survivors (median age at SCT: 11 ± 4.9 years; median time between SCT and testing: 8.25 years, 19 males) using a reduced version of the pediatric-modified total neuropathy score for clinical assessment and Quantitative Sensory Testing (QST). Inclusion criteria: ≥ 6 years old at testing, ≤ 18 years old at time of SCT, ≥ 1 year between SCT and testing.
Results: Nine patients (36%) had peripheral neuropathy as defined by the clinical red-pmTNS (≥ 4). The QST parameters mechanical pain sensitivity, mechanical detection threshold, thermal sensory limen, vibration detection threshold and pressure pain threshold were significantly abnormal in the survivor cohort (p < 0.0038). Except for one, all survivors showed at least one abnormal QST parameter. When using QST, signs of small and large fiber dysfunction were present in 22 (88%) and 17 (68%) survivors, respectively. More than half of all survivors were found to experience pathologic sensitization to pain.
Conclusions and implications for cancer survivors: Survivors of pediatric acute lymphoblastic leukemia after SCT are at high risk for long-term peripheral neuropathy with a dominating small-fiber and pain sensitization pattern.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Acute lymphoblastic leukemia
en
dc.subject
Chemotherapy-induced peripheral neuropathy
en
dc.subject
Quantitative sensory testing
en
dc.subject
Small- and large nerve fibers
en
dc.subject
Pain sensitization
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Long-term small-fiber neuropathy and pain sensitization in survivors of pediatric acute lymphoblastic leukemia after stem cell transplantation
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1007/s00432-020-03216-8
dcterms.bibliographicCitation.journaltitle
Journal of Cancer Research and Clinical Oncology
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.pagestart
2143
dcterms.bibliographicCitation.pageend
2152
dcterms.bibliographicCitation.volume
146
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32346759
dcterms.isPartOf.issn
0171-5216
dcterms.isPartOf.eissn
1432-1335