dc.contributor.author
Álvaro-Benito, Miguel
dc.date.accessioned
2022-11-30T12:27:51Z
dc.date.available
2022-11-30T12:27:51Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/36233
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-35949
dc.description.abstract
Identifying causal genetic variants for a given phenotype improves diagnosis and provides insights for designing therapies. However, defining the link and/or contribution to a phenotype of rare variants or those with an indirect contribution to disease remains challenging. These variants, however, are key for personalized and precision medicine strategies [1]. In this context, human leukocyte antigens of class II alleles (HLAIIs) facilitate activation of CD4+ T cells and are directly linked to various phenotypes. Non-classical HLAII (ncHLAII) molecules modulate HLAII function and their impact on T-cell responses. The contribution of ncHLAII to phenotypes has been investigated in knockout vs. wild-type cellular and animal models, and recent studies have shown that genetic variants altering the protein-coding regions of these molecules contribute to tuning of HLAII function [2]. These findings suggest that ncHLAII natural variants may play a key role in modulating immune mechanisms that affect human phenotypes.
en
dc.format.extent
3 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Cellular immunity
en
dc.subject
ncHLAII natural variants
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.title
Natural variation of ncHLAII molecules: challenges and perspectives
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1038/s41423-022-00910-0
dcterms.bibliographicCitation.journaltitle
Cellular & Molecular Immunology
dcterms.bibliographicCitation.number
12
dcterms.bibliographicCitation.pagestart
1432
dcterms.bibliographicCitation.pageend
1434
dcterms.bibliographicCitation.volume
19
dcterms.bibliographicCitation.url
https://doi.org/10.1038/s41423-022-00910-0
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie
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refubium.funding
Springer Nature DEAL
refubium.note.author
Die Publikation wurde aus Open Access Publikationsgeldern der Freien Universität Berlin gefördert.
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2042-0226