dc.contributor.author
Haslacher, David
dc.contributor.author
Novkovic, Nikolina
dc.contributor.author
Buthut, Maria
dc.contributor.author
Heinz, Andreas
dc.contributor.author
Soekadar, Surjo R.
dc.date.accessioned
2022-09-05T12:54:38Z
dc.date.available
2022-09-05T12:54:38Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/36182
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-35898
dc.description.abstract
Background: Hallucinogen persisting perception disorder (HPPD) is characterized by spontaneous recurrence of visual hallucinations or disturbances after previous consumption of hallucinogens, such as lysergic acid diethylamide (LSD). The underlying physiological mechanisms are unknown and there is no standardized treatment strategy available.
Case Presentation: A 33-year-old male patient presented with persistent visual distortions (halos around objects, intensified colors, positive after images, and trails following moving objects) that developed after repeated use of hallucinogenic drugs at the age of 18. Symptoms developed gradually and worsened several months later, resulting in various pharmacological and psychosocial treatment attempts that remained unsuccessful, however. At presentation, 32-channel electroencephalography (EEG) showed increased delta activity over the occipital brain regions, reminiscent of occipital intermittent rhythmic delta activity (OIRDA) usually seen in children. Two sessions of cathodal (inhibitory) transcranial direct current stimulation (tDCS) over 30 min attenuated visual hallucinations and occipital delta activity by approximately 60%. The response persisted for over four weeks.
Conclusion: Pathological delta activity over occipital brain regions may play an important role in the development and perpetuation of HPPD and can be attenuated by non-invasive brain stimulation.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
hallucinogen persisting perception disorder (HPPD)
en
dc.subject
transcranial direct current stimulation (tDCS)
en
dc.subject
delta oscillations
en
dc.subject
excitation/inhibition
en
dc.subject
non-invasive brain stimulation (NIBS)
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Pathological Delta Oscillations in Hallucinogen Persisting Perception Disorder: A Case Report
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
867314
dcterms.bibliographicCitation.doi
10.3389/fpsyt.2022.867314
dcterms.bibliographicCitation.journaltitle
Frontiers in Psychiatry
dcterms.bibliographicCitation.originalpublishername
Frontiers Media SA
dcterms.bibliographicCitation.volume
13
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
35401281
dcterms.isPartOf.eissn
1664-0640