dc.contributor.author
Krenzien, Felix
dc.contributor.author
Nevermann, Nora
dc.contributor.author
Krombholz, Alina
dc.contributor.author
Benzing, Christian
dc.contributor.author
Haber, Philipp
dc.contributor.author
Fehrenbach, Uli
dc.contributor.author
Lurje, Georg
dc.contributor.author
Pelzer, Uwe
dc.contributor.author
Pratschke, Johann
dc.contributor.author
Schmelzle, Moritz
dc.contributor.author
Schöning, Wenzel
dc.date.accessioned
2022-09-05T07:56:58Z
dc.date.available
2022-09-05T07:56:58Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/36151
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-35867
dc.description.abstract
Intrahepatic cholangiocarcinoma (iCC) is distinguished as an entity from perihilar and distal cholangiocarcinoma and gallbladder carcinoma. Recently, molecular profiling and histopathological features have allowed further classification. Due to the frequent delay in diagnosis, the prognosis for iCC remains poor despite major technical advances and multimodal therapeutic approaches. Liver resection represents the therapeutic backbone and only curative treatment option, with the functional residual capacity of the liver and oncologic radicality being deciding factors for postoperative and long-term oncological outcome. Furthermore, in selected cases and depending on national guidelines, liver transplantation may be a therapeutic option. Given the often advanced tumor stage at diagnosis or the potential for postoperative recurrence, locoregional therapies have become increasingly important. These strategies range from radiofrequency ablation to transarterial chemoembolization to selective internal radiation therapy and can be used in combination with liver resection. In addition, adjuvant and neoadjuvant chemotherapies as well as targeted therapies and immunotherapies based on molecular profiles can be applied. This review discusses multimodal treatment strategies for iCC and their differential use.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
intrahepatic cholangiocarcinoma
en
dc.subject
liver resection
en
dc.subject
liver transplantation
en
dc.subject
neoadjuvant therapy
en
dc.subject
hepatocellular
en
dc.subject
liver neoplasms
en
dc.subject
chemoembolization
en
dc.subject
therapeutic cholangiocarcinoma
en
dc.subject
radiofrequency ablation
en
dc.subject
immunotherapy
en
dc.subject
functional residual capacity
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Treatment of Intrahepatic Cholangiocarcinoma—A Multidisciplinary Approach
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
362
dcterms.bibliographicCitation.doi
10.3390/cancers14020362
dcterms.bibliographicCitation.journaltitle
Cancers
dcterms.bibliographicCitation.number
2
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
14
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
35053523
dcterms.isPartOf.eissn
2072-6694