dc.contributor.author
Sehouli, Jalid
dc.contributor.author
Heise, Kathrin
dc.contributor.author
Richter, Rolf
dc.contributor.author
Woopen, Hannah
dc.contributor.author
Anders, Louise
dc.contributor.author
Inci, Melisa Guelhan
dc.date.accessioned
2022-07-20T13:12:46Z
dc.date.available
2022-07-20T13:12:46Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/35607
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-35321
dc.description.abstract
Purpose: The aim of this study was to investigate preoperative quality of life (QoL) as a predictive tool for severe postoperative complications (POC) in gynecological cancer surgery.
Methods: This is a prospective study of patients undergoing gynecologic cancer surgery at an academic center in Germany. QoL was assessed by the EORTC Quality of Life Questionnaire (QLQ-C30) and the NCCN Distress Thermometer (DT). Several geriatric assessment tools have been applied. POC were graded using Clavien–Dindo criteria. Using multivariable logistic regression models, we identified predictive clinical characteristics for postoperative complications.
Results: Within 30 days of surgery, 40 patients (18%) experienced grade ≥ 3b complications including 9 patients (4%) who died. The dominant complication was anastomosis insufficiency with 13 patients (5.8%). In the multivariable stepwise logistic regression through all univariate significant variables, we found that impaired physical functioning was predictive of POC, defined by an EORTC score < 70 (OR 5.08, 95% CI 2.23–11.59, p < 0.001). Regarding symptoms nausea/vomiting assessed as an EORTC score > 20 (OR 3.08, 95% CI 1.15–8.26, p = 0.025) indicated a significant predictive value. Being overweight or obese (BMI > 25) were also identified as predictive factors (OR 5.44, 95% CI 2.04–14.49, p = 0.001) as were reduced Mini Mental State Examination (MMSE) results < 27 (OR 7.94, 95% CI 1.36–45.46, p = 0.02).
Conclusion: Preoperative QoL measurements could help to predict postoperative complications in patients with gynecological cancer. Patients with limitations of mobility, debilitating symptoms and cognitive impairment have an increased risk for developing severe POC.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Quality of life (QoL)
en
dc.subject
Postoperative complications
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Preoperative quality of life as prediction for severe postoperative complications in gynecological cancer surgery: results of a prospective study
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1007/s00404-020-05847-1
dcterms.bibliographicCitation.journaltitle
Archives of Gynecology and Obstetrics
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.pagestart
1057
dcterms.bibliographicCitation.pageend
1063
dcterms.bibliographicCitation.volume
303
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33119788
dcterms.isPartOf.issn
0932-0067
dcterms.isPartOf.eissn
1432-0711