dc.contributor.author
Tappe-Theodor, Anke
dc.contributor.author
Pitzer, Claudia
dc.contributor.author
Lewejohann, Lars
dc.contributor.author
Jirkof, Paulin
dc.contributor.author
Siegeler, Katja
dc.contributor.author
Segelcke, Astra
dc.contributor.author
Drude, Natascha
dc.contributor.author
Pradier, Bruno
dc.contributor.author
Pogatzki-Zahn, Esther
dc.contributor.author
Hollinderbäumer, Britta
dc.date.accessioned
2022-05-25T07:30:35Z
dc.date.available
2022-05-25T07:30:35Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/35155
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-34872
dc.description.abstract
The prospective severity assessment in animal experiments in the categories' non-recovery, mild, moderate, and severe is part of each approval process and serves to estimate the harm/benefit. Harms are essential for evaluating ethical justifiability, and on the other hand, they may represent confounders and effect modifiers within an experiment. Catalogs and guidelines provide a way to assess the experimental severity prospectively but are limited in adaptation due to their nature of representing particular examples without clear explanations of the assessment strategies. To provide more flexibility for current and future practices, we developed the modular Where-What-How (WWHow) concept, which applies findings from pre-clinical studies using surgical-induced pain models in mice and rats to provide a prospective severity assessment. The WWHow concept integrates intra-operative characteristics for predicting the maximum expected severity of surgical procedures. The assessed severity categorization is mainly congruent with examples in established catalogs; however, because the WWHow concept is based on anatomical location, detailed analysis of the tissue trauma and other intra-operative characteristics, it enables refinement actions, provides the basis for a fact-based dialogue with authority officials and other stakeholders, and helps to identify confounder factors of study findings.
en
dc.format.extent
13 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
postoperative
en
dc.subject
surgery surgical procedures
en
dc.subject
severity assessment
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
dc.title
The “WWHow” Concept for Prospective Categorization of Post-operative Severity Assessment in Mice and Rats
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
841431
dcterms.bibliographicCitation.doi
10.3389/fvets.2022.841431
dcterms.bibliographicCitation.journaltitle
Frontiers in Veterinary Science
dcterms.bibliographicCitation.volume
9
dcterms.bibliographicCitation.url
https://doi.org/10.3389/fvets.2022.841431
refubium.affiliation
Veterinärmedizin
refubium.affiliation.other
Institut für Tierschutz, Tierverhalten und Versuchstierkunde

refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2297-1769
refubium.resourceType.provider
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