dc.contributor.author
Schneider, Joanna
dc.contributor.author
Mohr, Naomi
dc.contributor.author
Aliatakis, Niko
dc.contributor.author
Seidel, Ulrich
dc.contributor.author
John, Rainer
dc.contributor.author
Promnitz, Gabriel
dc.contributor.author
Spors, Birgit
dc.contributor.author
Kaindl, Angela M
dc.date.accessioned
2022-03-15T16:16:24Z
dc.date.available
2022-03-15T16:16:24Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/34401
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-34119
dc.description.abstract
Aim To systematically characterize radiological features of patients with spina bifida, their relationship to cognitive function, and differences between spina bifida aperta (SBA) and spina bifida occulta (SBO). Method In a retrospective study of 265 patients (117 females, 148 males; median age at imaging 11y, range 1-47y; SBA n=206, SBO n=59), the radiological phenotype was assessed through magnetic resonance imaging (MRI) (SBA n=171, SBO n=59). In 126 patients (SBA n=116, SBO n=10) Kaufman Assessment Battery for Children (KABC) or Wechsler Intelligence Scale for Children, Fourth Edition (WISC-IV) and Wechsler Adult Intelligence Scale, Fourth Edition (WAIS-IV) were performed. Results Patients with spina bifida show numerous brain malformations, always present for SBA but rarely for SBO. The most frequent brain malformations in SBA included abnormal corpus callosum (69%), hypoplastic pons (50%), and hypoplastic mesencephalon (20%). Cognitive total IQ scores were below average in 44% (KABC) to 49% (WISC-IV) of children with SBA, while almost all children with SBO scored at least average. Stenogyria (p=0.006), pons (p=0.003), and mesencephalon hypoplasia (p=0.01) correlated with lower total IQ score and verbal comprehension. Various brain malformations correlate significantly with several cognitive domains, while lesion level only correlates with processing speed. Interpretation IQ scores were significantly lower in patients with SBA than in patients with SBO. Verbal competence, perceptual reasoning, and working memory were significantly impaired for SBA and correlated with stenogyria and abnormalities of the midbrain and corpus callosum.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject
spina bifida
en
dc.subject
brain malformations
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Brain malformations and cognitive performance in spina bifida
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1111/dmcn.14717
dcterms.bibliographicCitation.journaltitle
Developmental Medicine & Child Neurology
dcterms.bibliographicCitation.number
3
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.pagestart
295
dcterms.bibliographicCitation.pageend
302
dcterms.bibliographicCitation.volume
63
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33140418
dcterms.isPartOf.issn
0012-1622
dcterms.isPartOf.eissn
1469-8749