dc.contributor.author
Forsat, Noah D.
dc.contributor.author
Palmowski, Andriko
dc.contributor.author
Palmowski, Yannick
dc.contributor.author
Boers, Maarten
dc.contributor.author
Buttgereit, Frank
dc.date.accessioned
2022-02-28T10:52:19Z
dc.date.available
2022-02-28T10:52:19Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/34219
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-33937
dc.description.abstract
OBJECTIVE:
To identify barriers and solutions for the recruitment and retention of older (aged ≥65 years) people in clinical trials.
DESIGN:
Systematic literature review.
METHODS:
Three databases (Medline, Embase, and CENTRAL) were searched for articles reporting on barriers or solutions regarding the recruitment or retention of older people. Only original research articles were included.
RESULTS:
Fifty eligible articles were identified. Exclusion criteria were the most common cause of poor recruitment of older adults (mainly age and comorbidities). Patients' families or physicians often advised against participation (22% of included studies). Lack of interest (18%) and problems with transportation (18%) were also commonly cited as challenges. Fourteen trials (28%) reported that monitoring and adapting their recruitment methods helped, along with a flexible research team (26%) and provision of transportation (24%). Retention was impaired by death (12%), illness (8%), and loss of interest (6%). Methods with a positive effect on retention included financial incentives and regular information about the progress of the study (12%), a low staff turnover (12%), flexibility in appointment making (10%), and expression of appreciation by the staff through letters, gifts, and cards to the participants (10%).
CONCLUSION:
We identified several barriers and have listed potential solutions that may improve recruitment and lead to fewer dropouts in trials involving older populations. Implementation of our findings may help mitigate the manifold challenges that come with running a trial with older people.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
older people
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Recruitment and Retention of Older People in Clinical Research: A Systematic Literature Review
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1111/jgs.16875
dcterms.bibliographicCitation.journaltitle
Journal of the American Geriatrics Society
dcterms.bibliographicCitation.number
12
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.pagestart
2955
dcterms.bibliographicCitation.pageend
2963
dcterms.bibliographicCitation.volume
68
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33075140
dcterms.isPartOf.issn
0002-8614
dcterms.isPartOf.eissn
1532-5415