dc.contributor.author
Neckel, Norbert
dc.contributor.author
Wagendorf, Pia
dc.contributor.author
Sachse, Claudia
dc.contributor.author
Stromberger, Carmen
dc.contributor.author
Vach, Kirstin
dc.contributor.author
Heiland, Max
dc.contributor.author
Nahles, Susanne
dc.date.accessioned
2022-02-23T15:33:21Z
dc.date.available
2022-02-23T15:33:21Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/34124
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-33842
dc.description.abstract
Objectives: The aim of this study was to investigate the influence of real implant-bed-specific radiation doses on peri-implant tissue health in head and neck cancer (HNC) patients after radiotherapy.
Material and methods: Specific radiation doses in the area of 81 implants, in 15 irradiated HNC patients, were analyzed by matching data from the radiotherapy planning system with those of three-dimensional follow-up scans after implantation. Peri-implant bone resorption was measured radiographically after 1 and 3 years, and peri-implant tissue health was evaluated clinically. Individual parameters, such as age, gender, and localization, regarding the implant-specific radiation dose distribution were analyzed statistically.
Results: The mean implant-bed-specific radiation dose was high, with 45.95 Gy to the mandible and 29.02 Gy to the maxilla, but significantly lower than the mean total dose to the tumor bed. Peri-implant bone resorption correlated with local inflammation and plaque. After 1 year, women temporarily showed significantly more bone loss than men and implant-specific radiation dose had a significant impact on peri-implant bone loss after 3 years.
Conclusions: The presented method is a feasible option to define precise implant-bed-specific radiation doses for research or treatment planning purposes. Implant-based dental restoration after radiotherapy is a relatively safe procedure, but a negative radiation dose-dependent long-term effect on peri-implant bone resorption calls for interdisciplinary cooperation between surgeons and radio-oncologists to define high-risk areas.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
clinical research
en
dc.subject
clinical trials
en
dc.subject
clinical assessment
en
dc.subject
patient-centered outcomes
en
dc.subject
soft tissue–implant interactions
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Influence of implant‐specific radiation doses on peri‐implant hard and soft tissue: An observational pilot study
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1111/clr.13696
dcterms.bibliographicCitation.journaltitle
Clinical Oral Implants Research
dcterms.bibliographicCitation.number
2
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.pagestart
249
dcterms.bibliographicCitation.pageend
261
dcterms.bibliographicCitation.volume
32
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33278849
dcterms.isPartOf.issn
0905-7161
dcterms.isPartOf.eissn
1600-0501