dc.contributor.author
Rosenthal, Annika
dc.contributor.author
Beck, Anne
dc.contributor.author
Zois, Evangelos
dc.contributor.author
Vollstädt‐Klein, Sabine
dc.contributor.author
Walter, Henrik
dc.contributor.author
Kiefer, Falk
dc.contributor.author
Lohoff, Falk W.
dc.contributor.author
Charlet, Katrin
dc.date.accessioned
2022-02-22T12:44:36Z
dc.date.available
2022-02-22T12:44:36Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/34101
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-33819
dc.description.abstract
Background: Aspects of self-control such as sensation seeking and impaired impulse control have been implicated in alcohol dependence (ALC). Conversely, sensation seeking has been ascribed a possible protective role in stress-related psychopathologies. We therefore examined gray matter (GM) morphology in individuals with ALC, focusing on differences in prefrontal regions that have been associated with self-control. Additionally, we accounted for differences in lifetime alcohol intake regarding self-control measures and cortical structures in ALC patients.
Methods: With voxel-based morphometry (VBM) focusing on prefrontal a priori defined regions of interest, we assessed a group of 62 detoxified ALC patients and 62 healthy controls (HC). ALC patients were subsequently divided into high (n = 9) and low consumers (n = 53). Self-control was assessed by use of the Barratt Impulsiveness Scale and the Sensation Seeking Scale.
Results: Compared to HC, ALC had significantly less GM volume in bilateral middle frontal gyrus (MFG) and right medial prefrontal cortex as well as in the right anterior cingulate. High-consuming ALC showed smaller GM in right orbitofrontal cortex as well as lower sensation seeking scores than low consumers. In low-consuming ALC, right MFG-GM was positively associated with magnitude of sensation seeking; particularly, larger MFG-GM correlated with greater thrill and adventure seeking.
Conclusion: Thus, our findings (i) indicate deficient GM volume in prefrontal areas related to self-control and (ii) might accentuate the phenotypic divergence of ALC patients and emphasize the importance of the development of individual treatment options.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject
Voxel-Based Morphometry
en
dc.subject
Sensation Seeking
en
dc.subject
Prefrontal Cortex
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Volumetric Prefrontal Cortex Alterations in Patients With Alcohol Dependence and the Involvement of Self‐Control
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1111/acer.14211
dcterms.bibliographicCitation.journaltitle
Alcoholism: Clinical and Experimental Research
dcterms.bibliographicCitation.number
12
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.pagestart
2514
dcterms.bibliographicCitation.pageend
2524
dcterms.bibliographicCitation.volume
43
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
31688973
dcterms.isPartOf.eissn
1530-0277