dc.contributor.author
Throm, Carolin Maria
dc.contributor.author
Wiora, Georg
dc.contributor.author
Reble, Carina
dc.contributor.author
Schleusener, Johannes
dc.contributor.author
Schanzer, Sabine
dc.contributor.author
Karrer, Hans
dc.contributor.author
Kolbe, Ludger
dc.contributor.author
Khazaka, Georg
dc.contributor.author
Meinke, Martina C.
dc.contributor.author
Lademann, Jürgen
dc.date.accessioned
2022-02-18T12:51:33Z
dc.date.available
2022-02-18T12:51:33Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/34065
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-33783
dc.description.abstract
The sun protection factor (SPF) values are currently determined using an invasive procedure, in which the volunteers are irradiated with ultraviolet (UV) light. Non-invasive approaches based on hybrid diffuse reflectance spectroscopy (HDRS) have shown a good correlation with conventional SPF testing. Here, we present a novel compact and adjustable DRS test system. The in vivo measurements were performed using a multi-lambda-LED light source and an 84-channel imaging spectrograph with a fiber optic probe for detection. A transmission spectrum was calculated based on the reflectance measured with sunscreen and the reflectance measured without sunscreen. The preexposure in vitro spectrum was fitted to the in vivo spectrum. Each of the 11 test products was investigated on 10 volunteers. The SPF and UVA-PF values obtained by this new approach were compared with in vivo SPF results determined by certified test institutes. A correlation coefficient R-2 = 0.86 for SPF, and R-2 = 0.92 for UVA-PF were calculated. Having examined various approaches to apply the HDRS principle, the method we present was found to produce valid and reproducible results, suggesting that the multi-lambda-LED device is suitable for in-vivo SPF testing based on the HDRS principle as well as for in-vivo UVA-PF measurements.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject
non-erythemal testing
en
dc.subject
non-invasive
en
dc.subject
SPF determination by HDRS
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
In vivo sun protection factor and UVA protection factor determination using (hybrid) diffuse reflectance spectroscopy and a multi‐lambda‐LED light source
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e202000348
dcterms.bibliographicCitation.doi
10.1002/jbio.202000348
dcterms.bibliographicCitation.journaltitle
Journal of Biophotonics
dcterms.bibliographicCitation.number
2
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.volume
14
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33025740
dcterms.isPartOf.issn
1864-063X
dcterms.isPartOf.eissn
1864-0648