dc.contributor.author
Jiménez‐Fernández, Sara
dc.contributor.author
Gurpegui, Manuel
dc.contributor.author
Garrote‐Rojas, Daniel
dc.contributor.author
Gutiérrez‐Rojas, Luis
dc.contributor.author
Carretero, María D.
dc.contributor.author
Correll, Christoph U.
dc.date.accessioned
2022-02-01T10:16:02Z
dc.date.available
2022-02-01T10:16:02Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/33819
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-33539
dc.description.abstract
Objective: To investigate oxidative stress markers and antioxidants in bipolar disorder (BD).
Methods: Electronic MEDLINE/PubMed/Cochrane-Library/Scopus/TripDatabase search until 06/30/2019 for studies comparing antioxidant or oxidative stress markers between BD and healthy controls (HCs). Standardized mean differences (SMD) and 95% confidence intervals (CIs) were calculated for ≥3 studies.
Results: Forty-four studies (n = 3,767: BD = 1,979; HCs = 1,788) reported on oxidative stress markers malondialdehyde (MDA), thiobarbituric acid reactive substances (TBARS), and total nitrites; antioxidants glutathione (GSH), uric acid, and zinc; or antioxidantenhancing enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and GSH-transferase (GST). Compared with HCs, BD was associated with higher GST (P = .01), CAT (P = .02), nitrites (P < .0001), TBARS (P < .0001), MDA (P = .01), uric acid (P < .0001), and lower GSH (P = .006), without differences in SOD, GPX, and zinc. Compared to HCs, levels were higher in BD-mania for TBARS (P < .0001) and uric acid (P < .0001); in BD-depression for TBARS (P = .02); and BD-euthymia for uric acid (P = .03). Uric acid levels were higher in BD-mania vs BD-depression (P = .002), but not vs BD euthymia. TBARS did not differ between BD-mania and BD-depression. Medication-free BD-mania patients had higher SOD (P = .02) and lower GPX (P < .0001) than HCs. After treatment, BD did not differ from HCs regarding SOD and GPX.
Conclusions: Beyond a single biomarker of oxidative stress, the combination of several parameters appears to be more informative for BD in general and taking into account illness polarity. BD is associated with an imbalance in oxidative stress with some phase-specificity for uric acid and TBARS and possible treatment benefits for SOD and GPX. Future studies should take into account confounding factors that can modify oxidative stress status and simultaneously measure oxidative stress markers and antioxidants including different blood sources.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
antioxidants
en
dc.subject
bipolar disorder
en
dc.subject
meta-analysis
en
dc.subject
oxidative stress
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Oxidative stress parameters and antioxidants in patients with bipolar disorder: Results from a meta‐analysis comparing patients, including stratification by polarity and euthymic status, with healthy controls
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1111/bdi.12980
dcterms.bibliographicCitation.journaltitle
Bipolar Disorders
dcterms.bibliographicCitation.number
2
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.pagestart
117
dcterms.bibliographicCitation.pageend
129
dcterms.bibliographicCitation.volume
23
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32780547
dcterms.isPartOf.issn
1398-5647
dcterms.isPartOf.eissn
1399-5618