dc.contributor.author
Dobrindt, Eva M.
dc.contributor.author
Allex, Laura
dc.contributor.author
Saipbaev, Akylbek
dc.contributor.author
Öllinger, Robert
dc.contributor.author
Schöning, Wenzel
dc.contributor.author
Pratschke, Johann
dc.contributor.author
Eurich, Dennis
dc.date.accessioned
2021-12-02T16:23:15Z
dc.date.available
2021-12-02T16:23:15Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32974
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-32700
dc.description.abstract
Background Nonalcoholic steatohepatitis has become one of the leading causes of liver transplantation. The development of steatosis, as well as the link to inflammation and fibrosis, after transplantation remain poorly understood. The aim of this analysis was to evaluate the influence of obesity on histopathological changes of the graft during long-term follow-up. Methods A total of 1494 longitudinal liver biopsies of 271 recipients were evaluated during a follow-up period of 5 to 10 years. Clinical and laboratory parameters as well as histopathological categories of steatosis, inflammation, and fibrosis were explored by routine protocol biopsies. Results The BMI and prevalence of diabetes mellitus significantly increased after transplantation (P < .01). Diabetes and de novo obesity were significantly associated with the degree of graft steatosis. There was no correlation between former steatosis and inflammation or fibrosis. Inflammation was a precursor of fibrosis, and fibrosis increased over the first 3 years (P < .01). No severe graft dysfunction was observed. Conclusion Obesity and diabetes mellitus correlated with higher grades of steatosis and de novo steatosis after transplantation. Metabolic syndrome must be considered as a serious post-transplant complication that can cause histopathological alteration. However, the progress from steatosis to steatohepatitis is not as common as expected.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
metabolic complications
en
dc.subject
metabolic syndrome
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Association between obesity after liver transplantation and steatosis, inflammation, and fibrosis of the graft
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e14093
dcterms.bibliographicCitation.doi
10.1111/ctr.14093
dcterms.bibliographicCitation.journaltitle
Clinical Transplantation
dcterms.bibliographicCitation.number
12
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.volume
34
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32970896
dcterms.isPartOf.issn
0902-0063
dcterms.isPartOf.eissn
1399-0012