dc.contributor.author
Kermer, Josephine
dc.contributor.author
Traber, Julius
dc.contributor.author
Utz, Wolfgang
dc.contributor.author
Hennig, Pierre
dc.contributor.author
Menza, Marius
dc.contributor.author
Jung, Bernd
dc.contributor.author
Greiser, Andreas
dc.contributor.author
Barckow, Philipp
dc.contributor.author
Knobelsdorff‐Brenkenhoff, Florian von
dc.contributor.author
Töpper, Agnieszka
dc.contributor.author
Blaszczyk, Edyta
dc.contributor.author
Schulz‐Menger, Jeanette
dc.date.accessioned
2021-11-16T11:06:29Z
dc.date.available
2021-11-16T11:06:29Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32729
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-32455
dc.description.abstract
Aims: Heart failure with preserved ejection fraction is still a diagnostic and therapeutic challenge, and accurate non-invasive diagnosis of left ventricular (LV) diastolic dysfunction (DD) remains difficult. The current study aimed at identifying the most informative cardiovascular magnetic resonance (CMR) parameters for the assessment of LVDD.
Methods and results: We prospectively included 50 patients and classified them into three groups: with DD (DD+, n = 15), without (DD-, n = 26), and uncertain (DD ±, n = 9). Diagnosis of DD was based on echocardiographic E/E', invasive LV end-diastolic pressure, and N-terminal pro-brain natriuretic peptide. CMR was performed at 1.5 T to assess LV and left atrial (LA) morphology, LV diastolic strain rate (SR) by tissue tracking and tagging, myocardial peak velocities by tissue phase mapping, and transmitral inflow profile using phase contrast techniques. Statistics were performed only on definitive DD+ and DD- (total number 41). DD+ showed enlarged LA with LA end-diastolic volume/height performing best to identify DD+ with a cut-off value of ≥ 0.52 mL/cm (sensitivity = 0.71, specificity = 0.84, and area under the receiver operating characteristic curve = 0.75). DD+ showed significantly reduced radial (inferolateral E peak: DD-: -14.5 ± 6.5%/s vs. DD+: -10.9 ± 5.9%/s, P = 0.04; anterolateral A peak: DD-: -4.2 ± 1.6%/s vs. DD+: -3.1 ± 1.4%/s, P = 0.04) and circumferential (inferolateral A peak: DD-: 3.8 ± 1.2%/s vs. DD+: 2.8 ± 0.8%/s, P = 0.007; anterolateral A peak: DD-: 3.5 ± 1.2%/s vs. DD+: 2.5 ± 0.8%/s, P = 0.048) SR in the basal lateral wall assessed by tissue tracking. In the same segments, DD+ showed lower peak myocardial velocity by tissue phase mapping (inferolateral radial peak: DD-: -3.6 ± 0.7 ms vs. DD+: -2.8 ± 1.0 ms, P = 0.017; anterolateral longitudinal peak: DD-: -5.0 ± 1.8 ms vs. DD+: -3.4 ± 1.4 ms, P = 0.006). Tagging revealed reduced global longitudinal SR in DD+ (DD-: 45.8 ± 12.0%/s vs. DD+: 34.8 ± 9.2%/s, P = 0.022). Global circumferential and radial SR by tissue tracking and tagging, LV morphology, and transmitral flow did not differ between DD+ and DD-.
Conclusions: Left atrial size and regional quantitative myocardial deformation applying CMR identified best patients with DD.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Diastolic dysfunction
en
dc.subject
Cardiovascular magnetic resonance
en
dc.subject
Tissue tracking
en
dc.subject
Myocardial deformation
en
dc.subject
Heart failure with preserved ejection fraction
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Assessment of diastolic dysfunction: comparison of different cardiovascular magnetic resonance techniques
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1002/ehf2.12846
dcterms.bibliographicCitation.journaltitle
ESC Heart Failure
dcterms.bibliographicCitation.number
5
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.pagestart
2637
dcterms.bibliographicCitation.pageend
2649
dcterms.bibliographicCitation.volume
7
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32686332
dcterms.isPartOf.eissn
2055-5822