dc.contributor.author
Scherbakov, Nadja
dc.contributor.author
Szklarski, Marvin
dc.contributor.author
Hartwig, Jelka
dc.contributor.author
Sotzny, Franziska
dc.contributor.author
Lorenz, Sebastian
dc.contributor.author
Meyer, Antje
dc.contributor.author
Grabowski, Patricia
dc.contributor.author
Doehner, Wolfram
dc.contributor.author
Scheibenbogen, Carmen
dc.date.accessioned
2021-11-10T13:27:59Z
dc.date.available
2021-11-10T13:27:59Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32656
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-32380
dc.description.abstract
Aims
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex multisystem disease. Evidence for disturbed vascular regulation comes from various studies showing cerebral hypoperfusion and orthostatic intolerance. The peripheral endothelial dysfunction (ED) has not been sufficiently investigated in patients with ME/CFS. The aim of the present study was to examine peripheral endothelial function in patients with ME/CFS.
Methods and results
Thirty-five patients [median age 40 (range 18–70) years, mean body mass index 23.8 ± 4.2 kg/m2, 31% male] with ME/CFS were studied for peripheral endothelial function assessed by peripheral arterial tonometry (EndoPAT2000). Clinical diagnosis of ME/CFS was based on Canadian Criteria. Nine of these patients with elevated antibodies against β2-adrenergic receptor underwent immunoadsorption, and endothelial function was measured at baseline and 3, 6, and 12 months follow-up. ED was defined by reactive hyperaemia index ≤1.81. Twenty healthy subjects of similar age and body mass index were used as a control group. Peripheral ED was found in 18 of 35 patients (51%) with ME/CFS and in 4 healthy subjects (20%, P < 0.05). Patients with ED, in contrast to patients with normal endothelial function, reported more severe disease according to Bell score (31 ± 12 vs. 40 ± 16, P = 0.04), as well as more severe fatigue-related symptoms (8.62 ± 0.87 vs. 7.75 ± 1.40, P = 0.04) including a higher demand for breaks [9.0 (interquartile range 7.0–10.0) vs. 7.5 (interquartile range 6.0–9.25), P = 0.04]. Peripheral ED showed correlations with more severe immune-associated symptoms (r = −0.41, P = 0.026), such as sore throat (r = −0.38, P = 0.038) and painful lymph nodes (r = −0.37, P = 0.042), as well as more severe disease according to Bell score (r = 0.41, P = 0.008) and symptom score (r = −0.59, P = 0.005). There were no differences between the patient group with ED and the patient group with normal endothelial function regarding demographic, metabolic, and laboratory parameters. Further, there was no difference in soluble vascular cell adhesion molecule and soluble intercellular adhesion molecule levels. At baseline, peripheral ED was observed in six patients who underwent immunoadsorption. After 12 months, endothelial function had improved in five of these six patients (reactive hyperaemia index 1.58 ± 0.15 vs. 2.02 ± 0.46, P = 0.06).
Conclusions
Peripheral ED is frequent in patients with ME/CFS and associated with disease severity and severity of immune symptoms. As ED is a risk factor for cardiovascular disease, it is important to elucidate if peripheral ED is associated with increased cardiovascular morbidity and mortality in ME/CFS.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject
Chronic fatigue syndrome
en
dc.subject
Peripheral endothelial dysfunction
en
dc.subject
Cardiovascular risk factor
en
dc.subject
Reactive hyperaemia index
en
dc.subject
Immune score
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Peripheral endothelial dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1002/ehf2.12633
dcterms.bibliographicCitation.journaltitle
ESC Heart Failure
dcterms.bibliographicCitation.number
3
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.pagestart
1064
dcterms.bibliographicCitation.pageend
1071
dcterms.bibliographicCitation.volume
7
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32154656
dcterms.isPartOf.eissn
2055-5822