dc.contributor.author
Feinkohl, Insa
dc.date.accessioned
2021-11-11T14:59:14Z
dc.date.available
2021-11-11T14:59:14Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32652
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-32376
dc.description.abstract
Postoperative cognitive dysfunction (POCD) is characterized by a cognitive decline from pre- to post-surgery assessment, but is underresearched from an epidemiological perspective. Previous studies have identified metabolic dysfunction as a risk factor for age-related cognitive impairment (ACI) which too is characterized by cognitive deficits but occurs in the general population during ageing. Thus, metabolic dysfunction is a strong candidate risk factor for POCD. Here, I used a total of 4 surgical cohort studies of middle-aged to older adults with extensive anthropometric, clinical (and in part molecular) phenotyping as well as detailed pre- and post-surgical cognitive assessment to test the hypothesis that ACI and POCD share metabolic risk factors. I found partial evidence for in favor of this hypothesis. The implications of this work are three-fold: i) the findings suggest that ACI and POCD may (in part) be driven by similar pathophysiological mechanisms. ii) by measuring metabolic function before surgery, we may be able to risk stratify older surgical patients and – in elective surgery settings – empower at-risk patients for informed decision making. ii) if future work determines that the associations found here reflect causal relationships of metabolic dysfunction with ACI and POCD, we could set up preventive measures. Ultimately, the epidemiological analyses presented here provide one step towards a better understanding of ACI and POCD.
en
dc.rights.uri
http://www.fu-berlin.de/sites/refubium/rechtliches/Nutzungsbedingungen
dc.subject
epidemiology
en
dc.subject
cognitive impairment
en
dc.subject
Alzheimer's disease
en
dc.subject
post-operative cognitive dysfunction
en
dc.subject.ddc
600 Technology, Medicine, Applied sciences::610 Medical sciences; Medicine::610 Medical sciences; Medicine
dc.title
Metabolic risk factors for cognitive impairment in the perioperative setting
dc.contributor.gender
female
dc.contributor.firstReferee
Riedel-Heller, Steffi G.
dc.contributor.furtherReferee
Luck, Tobias
dc.date.accepted
2021-11-08
dc.identifier.urn
urn:nbn:de:kobv:188-refubium-32652-0
dc.title.translated
Metabolische Risikofaktoren für kognitive Dysfunktion im perioperativen Verlauf
en
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.note.author
Ich habe per Email die Erlaubnis von Karger Publishing erhalten, den Artikel in "Dementia & Geriatric Cognitive Disorders" als Teil der Habilitationsschrift in elektronischer Form in diesem Repositorium zu hinterlegen. Die 4 anderen Artikel, die ich in der Habilitationsschrift inkludiere, sind alle Open Access, also frei zugänglich.
de
dcterms.accessRights.dnb
free
dcterms.accessRights.openaire
open access
dcterms.accessRights.proquest
accept