dc.contributor.author
Jelgersma, Claudius
dc.contributor.author
Vajkoczy, Peter
dc.date.accessioned
2021-11-09T10:47:27Z
dc.date.available
2021-11-09T10:47:27Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32620
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-32344
dc.description.abstract
The spine is one of the organs that is most affected by metastasis in cancer patients. Since the control of primary tumor is continuously improving, treatment of metastases is becoming one of the major challenges to prevent cancer-related death. Due to the anatomical proximity to the spinal cord, local spread of metastasis can directly cause neurological deficits, severely limiting the patient's quality of life. To investigate the underlying mechanisms and to develop new therapies, preclinical models are required which represent the complexity of the multistep cascade of metastasis. Current research of metastasis focuses on the formation of the premetastatic niche, tumor cell dormancy and the influence and regulating function of the immune system. To unveil whether these influence the organotropism to the spine, spinal models are irreplaceable. Mouse models are one of the most suitable models in oncologic research. Therefore, this review provides an overview of currently used mouse models of spinal metastasis. Furthermore, it discusses technical aspects clarifying to what extend these models can picture key steps of the metastatic process. Finally, it addresses proposals to develop better mouse models in the future and could serve as both basis and stimulus for researchers and clinicians working in this field.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
spinal metastasis
en
dc.subject
multistep cascade
en
dc.subject
premetastatic niche
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
How to Target Spinal Metastasis in Experimental Research: An Overview of Currently Used Experimental Mouse Models and Future Prospects
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
5420
dcterms.bibliographicCitation.doi
10.3390/ijms22115420
dcterms.bibliographicCitation.journaltitle
International Journal of Molecular Sciences
dcterms.bibliographicCitation.number
11
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
22
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
34063821
dcterms.isPartOf.eissn
1422-0067