dc.contributor.author
Wu, Hao
dc.contributor.author
Han, Yijie
dc.contributor.author
Rodriguez Sillke, Yasmina
dc.contributor.author
Deng, Hongzhang
dc.contributor.author
Siddiqui, Sophiya
dc.contributor.author
Treese, Christoph
dc.contributor.author
Schmidt, Franziska
dc.contributor.author
Friedrich, Marie
dc.contributor.author
Keye, Jacqueline
dc.contributor.author
Wan, Jiajia
dc.contributor.author
Qin, Yue
dc.contributor.author
Kühl, Anja A.
dc.contributor.author
Qin, Zhihai
dc.contributor.author
Siegmund, Britta
dc.contributor.author
Glauben, Rainer
dc.date.accessioned
2021-11-08T13:54:59Z
dc.date.available
2021-11-08T13:54:59Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32605
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-32329
dc.description.abstract
Tumor-associated macrophages (TAMs) promote tumor growth and metastasis by suppressing tumor immune surveillance. Herein, we provide evidence that the immunosuppressive phenotype of TAMs is controlled by long-chain fatty acid metabolism, specifically unsaturated fatty acids, here exemplified by oleate. Consequently, en-route enriched lipid droplets were identified as essential organelles, which represent effective targets for chemical inhibitors to block in vitro polarization of TAMs and tumor growth in vivo. In line, analysis of human tumors revealed that myeloid cells infiltrating colon cancer but not gastric cancer tissue indeed accumulate lipid droplets. Mechanistically, our data indicate that oleate-induced polarization of myeloid cells depends on the mammalian target of the rapamycin pathway. Thus, our findings reveal an alternative therapeutic strategy by targeting the pro-tumoral myeloid cells on a metabolic level.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
cancer immunotherapy
en
dc.subject
lipid droplets
en
dc.subject
lipid metabolism
en
dc.subject
tumor microenvironment
en
dc.subject
tumor-associated macrophage
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Lipid droplet‐dependent fatty acid metabolism controls the immune suppressive phenotype of tumor‐associated macrophages
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e10698
dcterms.bibliographicCitation.doi
10.15252/emmm.201910698
dcterms.bibliographicCitation.journaltitle
EMBO Molecular Medicine
dcterms.bibliographicCitation.number
11
dcterms.bibliographicCitation.originalpublishername
EMBO
dcterms.bibliographicCitation.volume
11
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
31602788
dcterms.isPartOf.issn
1757-4676
dcterms.isPartOf.eissn
1757-4684