dc.contributor.author
Bourquain, Daniel
dc.contributor.author
Schrick, Livia
dc.contributor.author
Tischer, Bernd Karsten
dc.contributor.author
Osterrieder, Klaus
dc.contributor.author
Schaade, Lars
dc.contributor.author
Nitsche, Andreas
dc.date.accessioned
2021-11-03T12:23:15Z
dc.date.available
2021-11-03T12:23:15Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32493
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-32218
dc.description.abstract
Zoonotic orthopoxvirus infections continue to represent a threat to human health. The disease caused by distinct orthopoxviruses differs in terms of symptoms and severity, which may be explained by the unique repertoire of virus factors that modulate the host’s immune response and cellular machinery. We report here on the construction of recombinant cowpox viruses (CPXV) which either lack the host range factor p28 completely or express truncated variants of p28. We show that p28 is essential for CPXV replication in macrophages of human or mouse origin and that the C-terminal RING finger domain of p28 is necessary to allow CPXV replication in macrophages.
en
dc.format.extent
6 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Orthopoxvirus
en
dc.subject
Cowpox virus
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.title
Replication of cowpox virus in macrophages is dependent on the host range factor p28/N1R
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
173
dcterms.bibliographicCitation.doi
10.1186/s12985-021-01640-x
dcterms.bibliographicCitation.journaltitle
Virology Journal
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.volume
18
dcterms.bibliographicCitation.url
https://doi.org/10.1186/s12985-021-01640-x
refubium.affiliation
Veterinärmedizin
refubium.affiliation.other
Institut für Virologie

refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1743-422X
refubium.resourceType.provider
WoS-Alert